Measurement of the intrarenal arterial resistance index for the identification and prediction of diabetic nephropathy

M. Masulli, M. Mancini, R. Liuzzi, S. Daniele, P. P. Mainenti, E. Vergara, S. Genovese, M. Salvatore, O. Vaccaro

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aims: High intrarenal resistance index (RI) predicts renal function in several conditions; its use in the prediction of diabetic nephropathy (DN) is little explored. We aimed (1) to compare RI in diabetic and non diabetic hypertensive patients, and (2) to evaluate whether high RI is associated with clinical signs of DN and its progression over time. Methods and Results: Design: observational, prospective. Participants: 92 type 2 diabetic patients and 37 non-diabetic controls aged 40-70, with hypertension and normal renal function. We measured ultrasound RI and, among others, creatinine, estimated glomerular filtration rate and urinary albumin excretion rate (AER) at baseline and after 4.5 years follow-up. Progression of albuminuric state (i.e., transition from baseline normo-microalbuminuria to follow-up micro-macroalbuminuria) was evaluated. RI was significantly higher in diabetic than non-diabetic participants (0.69 ± 0.05 vs 0.59 ± 0.05, p <0.001). Diabetic patients with RI ≥ 0.73, i.e., above the 80th percentile of the RI distribution, had significantly higher baseline AER and a more frequent progression of the albuminuric state compared to patients with RI <0.73 (27.7 μg/mg [12.1-235.4] vs 15.1 μg/mg [8.6-33.4]; 52.9% vs 9.5%, respectively). AER increased significantly from baseline to follow-up in patients with RI ≥ 0.73 (from 27.7 μg/mg [12.1-235.4] to 265.0 μg/mg [23.8-1018.1], p <0.01), but not in those with RI <0.73 (from 15.1 μg/mg [8.6-33.4] to 16.1 μg/mg [10.7-67.2], ns). OR for progression of albuminuric state, adjusted for established predictors of DN, including baseline AER, was 5.01 (1.4-17.7, 95% CI) for patients with RI ≥ 0.73 vs

Original languageEnglish
Pages (from-to)358-364
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number5
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Diabetic nephropathy
  • Microalbuminuria
  • Renal resistance index
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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