Abstract
The measurement of plasma warfarin is required to investigate non-compliance, resistance to anticoagulation, drug metabolism and pharmacokinetic. Methods so far described are based on extraction of warfarin from plasma followed by reversed-phase HPLC. Extraction is the crucial step and may be performed in liquid- or solid-phase. The latter requires the preparation of columns, which makes the procedure variable. We investigated the suitability of the ready-for-use commercial cartridges for sample preparation. The method displayed between-run CV of 11.8%. Recovery was 99%. The coefficients of correlation between warfarin concentration in 50 patients and weekly dosage or INR were 0.55 (p
Original language | English |
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Pages (from-to) | 281-284 |
Number of pages | 4 |
Journal | Thrombosis Research |
Volume | 111 |
Issue number | 4-5 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Anticoagulation
- INR
- Thrombosis
- Warfarin
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology