Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy

Michela Marcenaro, Simona Sacco, Sara Pentimalli, Laura Berretta, Valeria Andretta, Rachels Grasso, Roberto Carlo Parodi, Marcelle Guarrera, Daniele Scarpati

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims and background: To confirm the equivalence in terms of late effects between two fractionation schedules of radiotherapy in conservative treatment of breast cancer. Methods: Fifty-eight patients treated at our institution from 1999 to 2002, with a median follow-up of 15 months (range, 7-46 months), were evaluated retrospectively. Twenty-nine patients (group A) were treated with standard fractionation: 5000 cGy/25fx/5 weeks, and 29 patients (group B) were treated with a hypofractionated schedule: 4500 cGy/15fx/5 weeks, three fractions per week. Late effects were evaluated using the LENT-SOMA scoring scale. The cosmetic results were assessed on a five-point scale. Skin elasticity was measured using a dedicated device (Cutometer SEM 575). Results: There were no differences in breast volume, age at diagnosis and follow-up between groups. The LENT-SOMA toxicity observed in groups A and B, respectively, was as follows: grade 2-3 pain in five patients in each group; grade 2 breast edema in two and three patients; frade 2-3 and grade 2 fibrosis in six and eight patients; grade and grade 2-3 telangiectasia in two and three patients; grade ≥2 and 2 arm edema in two and one patients; no ulceration or atrophy were observed. Two patients in group A and one patient in group B needed treatment for breast and arm edema and arm edema, respectively. Very good, good-acceptable, and poor cosmetic results were observed in seven and two, fifteen and nineteen, and six and eight patients, respectively. Median skin elasticity loss due to treatment was -4.19% in group A and -5.25% in group B. These results are not statistically different. Conclusions: LENT-SOMA toxicities were minimal and no differences were observed between groups. Few patients in the hypofractionated group had very good cosmetic results, but it is debatable if radiotherapy was the only cause. Skin elasticity was not different between groups. Our results seem to suggest that it is possible to treat patients with both schedules, with similar late toxicity.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalTumori
Volume90
Issue number6
Publication statusPublished - Nov 2004

Fingerprint

Radiotherapy
Breast Neoplasms
Edema
Elasticity
Cosmetics
Appointments and Schedules
Breast
Arm
Conservative Treatment
Skin
Telangiectasis
Atrophy
Fibrosis
Pain
Equipment and Supplies
Therapeutics

Keywords

  • Breast cancer
  • External beam radiotherapy
  • Hypofractionation
  • Late toxicity

ASJC Scopus subject areas

  • Cancer Research

Cite this

Marcenaro, M., Sacco, S., Pentimalli, S., Berretta, L., Andretta, V., Grasso, R., ... Scarpati, D. (2004). Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. Tumori, 90(6), 586-591.

Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. / Marcenaro, Michela; Sacco, Simona; Pentimalli, Sara; Berretta, Laura; Andretta, Valeria; Grasso, Rachels; Parodi, Roberto Carlo; Guarrera, Marcelle; Scarpati, Daniele.

In: Tumori, Vol. 90, No. 6, 11.2004, p. 586-591.

Research output: Contribution to journalArticle

Marcenaro, M, Sacco, S, Pentimalli, S, Berretta, L, Andretta, V, Grasso, R, Parodi, RC, Guarrera, M & Scarpati, D 2004, 'Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy', Tumori, vol. 90, no. 6, pp. 586-591.
Marcenaro M, Sacco S, Pentimalli S, Berretta L, Andretta V, Grasso R et al. Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. Tumori. 2004 Nov;90(6):586-591.
Marcenaro, Michela ; Sacco, Simona ; Pentimalli, Sara ; Berretta, Laura ; Andretta, Valeria ; Grasso, Rachels ; Parodi, Roberto Carlo ; Guarrera, Marcelle ; Scarpati, Daniele. / Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. In: Tumori. 2004 ; Vol. 90, No. 6. pp. 586-591.
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AU - Andretta, Valeria

AU - Grasso, Rachels

AU - Parodi, Roberto Carlo

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N2 - Aims and background: To confirm the equivalence in terms of late effects between two fractionation schedules of radiotherapy in conservative treatment of breast cancer. Methods: Fifty-eight patients treated at our institution from 1999 to 2002, with a median follow-up of 15 months (range, 7-46 months), were evaluated retrospectively. Twenty-nine patients (group A) were treated with standard fractionation: 5000 cGy/25fx/5 weeks, and 29 patients (group B) were treated with a hypofractionated schedule: 4500 cGy/15fx/5 weeks, three fractions per week. Late effects were evaluated using the LENT-SOMA scoring scale. The cosmetic results were assessed on a five-point scale. Skin elasticity was measured using a dedicated device (Cutometer SEM 575). Results: There were no differences in breast volume, age at diagnosis and follow-up between groups. The LENT-SOMA toxicity observed in groups A and B, respectively, was as follows: grade 2-3 pain in five patients in each group; grade 2 breast edema in two and three patients; frade 2-3 and grade 2 fibrosis in six and eight patients; grade and grade 2-3 telangiectasia in two and three patients; grade ≥2 and 2 arm edema in two and one patients; no ulceration or atrophy were observed. Two patients in group A and one patient in group B needed treatment for breast and arm edema and arm edema, respectively. Very good, good-acceptable, and poor cosmetic results were observed in seven and two, fifteen and nineteen, and six and eight patients, respectively. Median skin elasticity loss due to treatment was -4.19% in group A and -5.25% in group B. These results are not statistically different. Conclusions: LENT-SOMA toxicities were minimal and no differences were observed between groups. Few patients in the hypofractionated group had very good cosmetic results, but it is debatable if radiotherapy was the only cause. Skin elasticity was not different between groups. Our results seem to suggest that it is possible to treat patients with both schedules, with similar late toxicity.

AB - Aims and background: To confirm the equivalence in terms of late effects between two fractionation schedules of radiotherapy in conservative treatment of breast cancer. Methods: Fifty-eight patients treated at our institution from 1999 to 2002, with a median follow-up of 15 months (range, 7-46 months), were evaluated retrospectively. Twenty-nine patients (group A) were treated with standard fractionation: 5000 cGy/25fx/5 weeks, and 29 patients (group B) were treated with a hypofractionated schedule: 4500 cGy/15fx/5 weeks, three fractions per week. Late effects were evaluated using the LENT-SOMA scoring scale. The cosmetic results were assessed on a five-point scale. Skin elasticity was measured using a dedicated device (Cutometer SEM 575). Results: There were no differences in breast volume, age at diagnosis and follow-up between groups. The LENT-SOMA toxicity observed in groups A and B, respectively, was as follows: grade 2-3 pain in five patients in each group; grade 2 breast edema in two and three patients; frade 2-3 and grade 2 fibrosis in six and eight patients; grade and grade 2-3 telangiectasia in two and three patients; grade ≥2 and 2 arm edema in two and one patients; no ulceration or atrophy were observed. Two patients in group A and one patient in group B needed treatment for breast and arm edema and arm edema, respectively. Very good, good-acceptable, and poor cosmetic results were observed in seven and two, fifteen and nineteen, and six and eight patients, respectively. Median skin elasticity loss due to treatment was -4.19% in group A and -5.25% in group B. These results are not statistically different. Conclusions: LENT-SOMA toxicities were minimal and no differences were observed between groups. Few patients in the hypofractionated group had very good cosmetic results, but it is debatable if radiotherapy was the only cause. Skin elasticity was not different between groups. Our results seem to suggest that it is possible to treat patients with both schedules, with similar late toxicity.

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