Measuring and estimating GFR and treatment effect in ADPKD patients: Results and implications of a longitudinal cohort study

Piero Ruggenenti, Flavio Gaspari, Antonio Cannata, Fabiola Carrara, Claudia Cella, Silvia Ferrari, Nadia Stucchi, Silvia Prandini, Bogdan Ene-Iordache, Olimpia Diadei, Norberto Perico, Patrizia Ondei, Antonio Pisani, Erasmo Buongiorno, Piergiorgio Messa, Mauro Dugo, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR values centrally measured by iohexol plasma clearance with corresponding values estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and abbreviated Modification of Diet in Renal Disease (aMDRD) formulas in ADPKD patients retrieved from four clinical trials run by a Clinical Research Center and five Nephrology Units in Italy. Measured baseline GFRs and one-year GFR changes averaged 78.6±26.7 and 8.4±10.3 mL/min/1.73 m 2 in 111 and 71 ADPKD patients, respectively. CKD-Epi significantly overestimated and aMDRD underestimated baseline GFRs. Less than half estimates deviated by

Original languageEnglish
Article numbere32533
JournalPLoS One
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 28 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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