Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: Toward clinical applications

Stefan Teipel, Michel J. Grothe, Juan Zhou, Jorge Sepulcre, Martin Dyrba, Christian Sorg, Claudio Babiloni

Research output: Contribution to journalArticlepeer-review


Objectives: The objective was to review the literature on diffusion tensor imaging as well as resting-state functional magnetic resonance imaging and electroencephalography (EEG) to unveil neuroanatomical and neurophysiological substrates of Alzheimer's disease (AD) as a brain neural network pathology affecting structural and functional cortical connectivity underlying human cognition. Methods: We reviewed papers registered in PubMed and other scientific repositories on the use of these techniques in amnesic mild cognitive impairment (MCI) and clinically mild AD dementia patients compared to cognitively intact elderly individuals (Controls). Results: Hundreds of peer-reviewed (cross-sectional and longitudinal) papers have shown in patients with MCI and mild AD compared to Controls (1) impairment of callosal (splenium), thalamic, and anterior-posterior white matter bundles; (2) reduced correlation of resting state blood oxygen level-dependent activity across several intrinsic brain circuits including default mode and attention-related networks; and (3) abnormal power and functional coupling of resting state cortical EEG rhythms. Clinical applications of these measures are still limited. Conclusions: Structural and functional (in vivo) cortical connectivity measures represent a reliable marker of cerebral reserve capacity and should be used to predict and monitor the evolution of AD and its relative impact on cognitive domains in pre-clinical, prodromal, and dementia stages of AD.

Original languageEnglish
Pages (from-to)138-163
Number of pages26
JournalJournal of the International Neuropsychological Society
Issue number2
Publication statusPublished - Feb 18 2016


  • Dementia diagnosis
  • EEG
  • MRI
  • PET
  • Prognosis
  • Treatment trials

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language


Dive into the research topics of 'Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: Toward clinical applications'. Together they form a unique fingerprint.

Cite this