Measuring inflammation in paediatric severe asthma: Biomarkers in clinical practice

Amelia Licari, Sara Manti, Riccardo Castagnoli, Salvatore Leonardi, Gian Luigi Marseglia

Research output: Contribution to journalReview articlepeer-review

Abstract

Severe asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes). Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma. Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. However, in the absence of available point-of-care biomarkers, the diagnosis of non-type 2 asthma is still reached by exclusion. In this review, we present the most recent evidence on biomarkers for severe asthma and discuss their implementation in clinical practice. We address the methods for guiding treatment decisions and patient identification, focusing on the paediatric age group.

Original languageEnglish
Article number190301
JournalBreathe
Volume16
Issue number1
DOIs
Publication statusPublished - Mar 2020

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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