Measuring quality of life in dyspeptic patients: Development and validation of a new specific health status questionnaire: Final report from the Italian QPD project involving 4000 patients

Francesco Bamfi, Antonio Olivieri, Fabio Arpinelli, Gianfranco De Carli, Giuseppe Recchia, Lionello Gandolfi, Lorenzo Norberto, Franco Pacini, Calogero Surrenti, Sidney H. Irvine, Giovanni Apolone

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Despite the fact that gastrointestinal disorders represent one of the most common reasons for medical consultations, formal assessment of patients' health-related quality of life (HRQOL) has been carried out only in a few studies, and in most cases generic questionnaires have been adopted. Because the specific issue of living with dyspeptic problems has been addressed in very few cases and no questionnaire has been shown to be appropriate for the Italian setting, a prospective project was launched to develop a specific HRQOL questionnaire for dyspepsia sufferers tailored to Italian patients but also appropriate in other cultural settings. METHODS: The project consisted in a 3-yr, three-phase survey, in which different versions of the quality of life in peptic disease questionnaire (QPD) were developed through expert and patient focus groups and empiric field studies and then administered to patients recruited in five multicenter studies. Standard psychometric techniques were used to evaluate the validity, reliability, responsiveness, and patient acceptability of the QPD. RESULTS: Three different versions of the QPD questionnaire were self-administered to more than 4000 patients. The final 30-item version, measuring three health concepts related to dyspeptic disease (anxiety induced by pain, social restriction, symptom perception), fulfilled the recommended psychometric criteria in terms of reliability and validity, correlated with health concepts measured with a well-known independent generic HRQOL instrument (the SF-36 Health Survey questionnaire) and was relatively invariant to diagnosis and sociodemographic variables; it also correlated with a measure of gastric pain frequency and was able to detect meaningful differences over time. CONCLUSIONS: Although further validation studies in different cultural and linguistic settings are mandatory before any firm conclusions can be drawn regarding the cross-cultural validity of the QPD, the data obtained provide evidence of the psychometric validity and robustness of the questionnaire when used in a fairly large, well-characterized population of Italian dyspeptic patients.

Original languageEnglish
Pages (from-to)730-738
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 1999

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Health Status
Quality of Life
Psychometrics
Reproducibility of Results
Pain
Surveys and Questionnaires
Validation Studies
Dyspepsia
Health
Linguistics
Health Surveys
Focus Groups
Multicenter Studies
Digestion
Stomach
Referral and Consultation
Anxiety
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Measuring quality of life in dyspeptic patients : Development and validation of a new specific health status questionnaire: Final report from the Italian QPD project involving 4000 patients. / Bamfi, Francesco; Olivieri, Antonio; Arpinelli, Fabio; De Carli, Gianfranco; Recchia, Giuseppe; Gandolfi, Lionello; Norberto, Lorenzo; Pacini, Franco; Surrenti, Calogero; Irvine, Sidney H.; Apolone, Giovanni.

In: American Journal of Gastroenterology, Vol. 94, No. 3, 03.1999, p. 730-738.

Research output: Contribution to journalArticle

Bamfi, Francesco ; Olivieri, Antonio ; Arpinelli, Fabio ; De Carli, Gianfranco ; Recchia, Giuseppe ; Gandolfi, Lionello ; Norberto, Lorenzo ; Pacini, Franco ; Surrenti, Calogero ; Irvine, Sidney H. ; Apolone, Giovanni. / Measuring quality of life in dyspeptic patients : Development and validation of a new specific health status questionnaire: Final report from the Italian QPD project involving 4000 patients. In: American Journal of Gastroenterology. 1999 ; Vol. 94, No. 3. pp. 730-738.
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abstract = "OBJECTIVE: Despite the fact that gastrointestinal disorders represent one of the most common reasons for medical consultations, formal assessment of patients' health-related quality of life (HRQOL) has been carried out only in a few studies, and in most cases generic questionnaires have been adopted. Because the specific issue of living with dyspeptic problems has been addressed in very few cases and no questionnaire has been shown to be appropriate for the Italian setting, a prospective project was launched to develop a specific HRQOL questionnaire for dyspepsia sufferers tailored to Italian patients but also appropriate in other cultural settings. METHODS: The project consisted in a 3-yr, three-phase survey, in which different versions of the quality of life in peptic disease questionnaire (QPD) were developed through expert and patient focus groups and empiric field studies and then administered to patients recruited in five multicenter studies. Standard psychometric techniques were used to evaluate the validity, reliability, responsiveness, and patient acceptability of the QPD. RESULTS: Three different versions of the QPD questionnaire were self-administered to more than 4000 patients. The final 30-item version, measuring three health concepts related to dyspeptic disease (anxiety induced by pain, social restriction, symptom perception), fulfilled the recommended psychometric criteria in terms of reliability and validity, correlated with health concepts measured with a well-known independent generic HRQOL instrument (the SF-36 Health Survey questionnaire) and was relatively invariant to diagnosis and sociodemographic variables; it also correlated with a measure of gastric pain frequency and was able to detect meaningful differences over time. CONCLUSIONS: Although further validation studies in different cultural and linguistic settings are mandatory before any firm conclusions can be drawn regarding the cross-cultural validity of the QPD, the data obtained provide evidence of the psychometric validity and robustness of the questionnaire when used in a fairly large, well-characterized population of Italian dyspeptic patients.",
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AU - Arpinelli, Fabio

AU - De Carli, Gianfranco

AU - Recchia, Giuseppe

AU - Gandolfi, Lionello

AU - Norberto, Lorenzo

AU - Pacini, Franco

AU - Surrenti, Calogero

AU - Irvine, Sidney H.

AU - Apolone, Giovanni

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