Measuring the activity of the disease in patients with cutaneous lupus erythematosus

Aurora Parodi, C. Massone, M. Cacciapuoti, M. G. Aragone, P. Bondavalli, G. Cattarini, A. Rebora

Research output: Contribution to journalArticle

Abstract

The Systemic Lupus Activity Measure (SLAM) is a system proposed by rheumatologists to measure disease activity in their patients with systemic lupus erythematosus (LE). It involves scoring a group of clinical symptoms and laboratory findings, the maximum possible score being 84. In systemic LE, the mid-point is between 9 and 12. We applied SLAM to 176 patients with cutaneous LE. Ninety-seven had localized discoid LE (L-DLE), 59 had disseminated discoid LE (D-DLE) and 20 had subacute cutaneous LE (SCLE). Eighty-five patients had low activity disease (0-4 points), 72 mildly active disease (5-9 points), 15 moderately active disease (10-14 points) and only four had very active disease (≥ 15 points). The most frequent lesions in patients who scored more than 10 points were photosensitivity, cicatricial alopecia, Raynaud's phenomenon and oral ulcers. Fifty patients were followed up for more than 5 years (mean follow-up 9 years). Nine of these had an increased SLAM score. Seven had L-DLE, one D-DLE and one SCLE. Seven of the 50 patients had photosensitivity, five cicatricial alopecia, five non- cicatricial alopecia, two Raynaud's phenomenon and two oral ulcers. Three patients who started with L-DLE evolved to D-DLE. The SLAM system is useful in the monitoring of disease activity in patients with cutaneous LE. Over time, even L-DLE patients may develop active disease. Photosensitivity, alopecia, oral ulcers and Raynaud's phenomenon seem to herald a worse prognosis.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalBritish Journal of Dermatology
Volume142
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Cutaneous lupus erythematosus
  • Disease activity
  • Systemic Lupus Activity Measure

ASJC Scopus subject areas

  • Dermatology

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    Parodi, A., Massone, C., Cacciapuoti, M., Aragone, M. G., Bondavalli, P., Cattarini, G., & Rebora, A. (2000). Measuring the activity of the disease in patients with cutaneous lupus erythematosus. British Journal of Dermatology, 142(3), 457-460. https://doi.org/10.1046/j.1365-2133.2000.03356.x