Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Carlos A. González, Paula Jakszyn, Guillem Pera, Antonio Agudo, Sheila Bingham, Domenico Palli, Pietro Ferrari, Heiner Boeing, Giuseppe del Giudice, Mario Plebani, Fátima Carneiro, Gabriella Nesi, Franco Berrino, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Olof Nyrén, Göran HallmansCarmen Martinez, Miren Dorronsoro, Aurelio Barricarte, Carmen Navarro, José R. Quirós, Naomi Allen, Timothy J. Key, Nicholas E. Day, Jakob Linseisen, Gabriele Nagel, Manuela M. Bergmann, Kim Overvad, Majken K. Jensen, Anne Tjonneland, Anja Olsen, H. Bas Bueno-de-Mesquita, Marga Ocke, Petra H M Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Antonia Trichopoulou, Theodora Psaltopoulou, Dimitrios Roukos, Eiliv Lund, Bertrand Hemon, Rudolf Kaaks, Teresa Norat, Elio Riboli

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

Original languageEnglish
Pages (from-to)345-354
Number of pages10
JournalJournal of the National Cancer Institute
Volume98
Issue number5
DOIs
Publication statusPublished - Mar 2006

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Meat
Stomach
Adenocarcinoma
Stomach Neoplasms
Neoplasms
Helicobacter pylori
Cardia
Confidence Intervals
Antibodies
Helicobacter Infections
Esophageal Neoplasms
Proportional Hazards Models
Calibration
Case-Control Studies
Life Style
Carcinogenesis
Cohort Studies
Odds Ratio
Diet

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). / González, Carlos A.; Jakszyn, Paula; Pera, Guillem; Agudo, Antonio; Bingham, Sheila; Palli, Domenico; Ferrari, Pietro; Boeing, Heiner; del Giudice, Giuseppe; Plebani, Mario; Carneiro, Fátima; Nesi, Gabriella; Berrino, Franco; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Simán, Henrik; Nyrén, Olof; Hallmans, Göran; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Navarro, Carmen; Quirós, José R.; Allen, Naomi; Key, Timothy J.; Day, Nicholas E.; Linseisen, Jakob; Nagel, Gabriele; Bergmann, Manuela M.; Overvad, Kim; Jensen, Majken K.; Tjonneland, Anne; Olsen, Anja; Bueno-de-Mesquita, H. Bas; Ocke, Marga; Peeters, Petra H M; Numans, Mattijs E.; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Trichopoulou, Antonia; Psaltopoulou, Theodora; Roukos, Dimitrios; Lund, Eiliv; Hemon, Bertrand; Kaaks, Rudolf; Norat, Teresa; Riboli, Elio.

In: Journal of the National Cancer Institute, Vol. 98, No. 5, 03.2006, p. 345-354.

Research output: Contribution to journalArticle

González, CA, Jakszyn, P, Pera, G, Agudo, A, Bingham, S, Palli, D, Ferrari, P, Boeing, H, del Giudice, G, Plebani, M, Carneiro, F, Nesi, G, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Nyrén, O, Hallmans, G, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, TJ, Day, NE, Linseisen, J, Nagel, G, Bergmann, MM, Overvad, K, Jensen, MK, Tjonneland, A, Olsen, A, Bueno-de-Mesquita, HB, Ocke, M, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Boutron-Ruault, MC, Trichopoulou, A, Psaltopoulou, T, Roukos, D, Lund, E, Hemon, B, Kaaks, R, Norat, T & Riboli, E 2006, 'Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)', Journal of the National Cancer Institute, vol. 98, no. 5, pp. 345-354. https://doi.org/10.1093/jnci/djj071
González, Carlos A. ; Jakszyn, Paula ; Pera, Guillem ; Agudo, Antonio ; Bingham, Sheila ; Palli, Domenico ; Ferrari, Pietro ; Boeing, Heiner ; del Giudice, Giuseppe ; Plebani, Mario ; Carneiro, Fátima ; Nesi, Gabriella ; Berrino, Franco ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Nyrén, Olof ; Hallmans, Göran ; Martinez, Carmen ; Dorronsoro, Miren ; Barricarte, Aurelio ; Navarro, Carmen ; Quirós, José R. ; Allen, Naomi ; Key, Timothy J. ; Day, Nicholas E. ; Linseisen, Jakob ; Nagel, Gabriele ; Bergmann, Manuela M. ; Overvad, Kim ; Jensen, Majken K. ; Tjonneland, Anne ; Olsen, Anja ; Bueno-de-Mesquita, H. Bas ; Ocke, Marga ; Peeters, Petra H M ; Numans, Mattijs E. ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Trichopoulou, Antonia ; Psaltopoulou, Theodora ; Roukos, Dimitrios ; Lund, Eiliv ; Hemon, Bertrand ; Kaaks, Rudolf ; Norat, Teresa ; Riboli, Elio. / Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). In: Journal of the National Cancer Institute. 2006 ; Vol. 98, No. 5. pp. 345-354.
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title = "Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)",
abstract = "Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95{\%} confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95{\%} CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95{\%} CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95{\%} CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95{\%} CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26{\%} for the lowest quartile of total meat intake and 0.33{\%} for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.",
author = "Gonz{\'a}lez, {Carlos A.} and Paula Jakszyn and Guillem Pera and Antonio Agudo and Sheila Bingham and Domenico Palli and Pietro Ferrari and Heiner Boeing and {del Giudice}, Giuseppe and Mario Plebani and F{\'a}tima Carneiro and Gabriella Nesi and Franco Berrino and Carlotta Sacerdote and Rosario Tumino and Salvatore Panico and G{\"o}ran Berglund and Henrik Sim{\'a}n and Olof Nyr{\'e}n and G{\"o}ran Hallmans and Carmen Martinez and Miren Dorronsoro and Aurelio Barricarte and Carmen Navarro and Quir{\'o}s, {Jos{\'e} R.} and Naomi Allen and Key, {Timothy J.} and Day, {Nicholas E.} and Jakob Linseisen and Gabriele Nagel and Bergmann, {Manuela M.} and Kim Overvad and Jensen, {Majken K.} and Anne Tjonneland and Anja Olsen and Bueno-de-Mesquita, {H. Bas} and Marga Ocke and Peeters, {Petra H M} and Numans, {Mattijs E.} and Fran{\cc}oise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Antonia Trichopoulou and Theodora Psaltopoulou and Dimitrios Roukos and Eiliv Lund and Bertrand Hemon and Rudolf Kaaks and Teresa Norat and Elio Riboli",
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TY - JOUR

T1 - Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

AU - González, Carlos A.

AU - Jakszyn, Paula

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Bingham, Sheila

AU - Palli, Domenico

AU - Ferrari, Pietro

AU - Boeing, Heiner

AU - del Giudice, Giuseppe

AU - Plebani, Mario

AU - Carneiro, Fátima

AU - Nesi, Gabriella

AU - Berrino, Franco

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Nyrén, Olof

AU - Hallmans, Göran

AU - Martinez, Carmen

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Quirós, José R.

AU - Allen, Naomi

AU - Key, Timothy J.

AU - Day, Nicholas E.

AU - Linseisen, Jakob

AU - Nagel, Gabriele

AU - Bergmann, Manuela M.

AU - Overvad, Kim

AU - Jensen, Majken K.

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Bueno-de-Mesquita, H. Bas

AU - Ocke, Marga

AU - Peeters, Petra H M

AU - Numans, Mattijs E.

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Trichopoulou, Antonia

AU - Psaltopoulou, Theodora

AU - Roukos, Dimitrios

AU - Lund, Eiliv

AU - Hemon, Bertrand

AU - Kaaks, Rudolf

AU - Norat, Teresa

AU - Riboli, Elio

PY - 2006/3

Y1 - 2006/3

N2 - Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

AB - Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

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