Mechanism of action of the epidermal growth factor. Effect on the sulfhydryl and disulphide groups content of the mouse epidermis during keratinization

C. Frati, I. Covelli, R. Mozzi, L. Frati

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the epidermal growth factor (EGF) on the process of the keratinization occurring in the epidermal cells of new-born mice has been investigated. It has been demonstrated that during 7 days of treatment EGF accelerates the rate of differentiation (keratogenesis) of the epidermis and can produce hyperkeratosis. This phenomenon is accomplished by a chemically and histochemically evaluated increase of the disulphide groups content in the epidermal cells. At the same time the free -SH groups are markedly decreased in the same cells, thus suggesting an actual keratin formation. Studies performed on the endogenous oxygen consumption of epidermis have shown a significant (7.35-fold) increase of the efficiency of the intracellular oxidative systems of the epidermal cells of the EGF-treated with respect to that of the control mice.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalCell Differentiation
Volume1
Issue number4
DOIs
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Developmental Biology

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