The effect of the epidermal growth factor (EGF) on the process of the keratinization occurring in the epidermal cells of new-born mice has been investigated. It has been demonstrated that during 7 days of treatment EGF accelerates the rate of differentiation (keratogenesis) of the epidermis and can produce hyperkeratosis. This phenomenon is accomplished by a chemically and histochemically evaluated increase of the disulphide groups content in the epidermal cells. At the same time the free -SH groups are markedly decreased in the same cells, thus suggesting an actual keratin formation. Studies performed on the endogenous oxygen consumption of epidermis have shown a significant (7.35-fold) increase of the efficiency of the intracellular oxidative systems of the epidermal cells of the EGF-treated with respect to that of the control mice.
ASJC Scopus subject areas
- Developmental Biology