Mechanism of immune-mediated skin diseases: An overview

S. Beissert, I. Cavazzana, F. Mascia, P. Meroni, S. Pastore, G. Tessari, Giampiero Girolomoni

Research output: Contribution to journalArticlepeer-review


The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments. These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or auto-antibody-dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Issue numberSUPPL. 40
Publication statusPublished - Jan 2006


  • Anti-endothelial cell antibodies
  • Anti-fibroblast antibodies
  • Anti-Ro/SSA antibodies
  • Atopic dermatitis
  • Keratinocytes
  • Skin
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • T regulatory cells

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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