TY - JOUR
T1 - Mechanism of increased maternal serum total activin A and inhibin A in preeclampsia
AU - Silver, Helayne M.
AU - Lambert-Messerlian, Geralyn M.
AU - Reis, Fernando M.
AU - Diblasio, Anna Maria
AU - Petraglia, Felice
AU - Canick, Jacob A.
PY - 2002/9/10
Y1 - 2002/9/10
N2 - Objective: To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production. Study design: Activin A and inhibin A levels were measured in preeclamptic subjects and matched normotensive gravidas. In a subset of preeclamptic subjects (n = 21) and controls (n = 30), we performed blood volume studies. In an overlapping subset of preeclamptic subjects (n = 56), creatinine clearance results were available. Placental tissue was obtained from six preeclamptics and matched normotensive gravida for analysis of activin A and inhibin A mRNA expression. Results: Maternal serum levels of inhibin A but not activin A were significantly negatively correlated with blood volume in preeclampsia (r2 = .26, P = .017, and r2 = .02, P = .44, respectively). Levels of both proteins were negatively correlated to creatinine clearance (r2 = .29, P <.0001, and r2 = .15, P = .003, respectively). Placental mRNA expression for both the α and βA subunits was increased in preeclampsia (P = .038 and .049, respectively). Conclusion: Although placental mRNA expression of the subunits for both analytes is increased in preeclampsia, the increased levels of activin A appear to be more specifically a reflection of increased placental production than do the increased levels of inhibin A.
AB - Objective: To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production. Study design: Activin A and inhibin A levels were measured in preeclamptic subjects and matched normotensive gravidas. In a subset of preeclamptic subjects (n = 21) and controls (n = 30), we performed blood volume studies. In an overlapping subset of preeclamptic subjects (n = 56), creatinine clearance results were available. Placental tissue was obtained from six preeclamptics and matched normotensive gravida for analysis of activin A and inhibin A mRNA expression. Results: Maternal serum levels of inhibin A but not activin A were significantly negatively correlated with blood volume in preeclampsia (r2 = .26, P = .017, and r2 = .02, P = .44, respectively). Levels of both proteins were negatively correlated to creatinine clearance (r2 = .29, P <.0001, and r2 = .15, P = .003, respectively). Placental mRNA expression for both the α and βA subunits was increased in preeclampsia (P = .038 and .049, respectively). Conclusion: Although placental mRNA expression of the subunits for both analytes is increased in preeclampsia, the increased levels of activin A appear to be more specifically a reflection of increased placental production than do the increased levels of inhibin A.
KW - Activin A
KW - Gestational hypertension
KW - Inhibin A
KW - Preeclampsia
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U2 - 10.1016/S1071-5576(02)00165-X
DO - 10.1016/S1071-5576(02)00165-X
M3 - Article
C2 - 12383916
AN - SCOPUS:0037057156
VL - 9
SP - 308
EP - 312
JO - Journal of the Society for Gynecologic Investigation
JF - Journal of the Society for Gynecologic Investigation
SN - 1071-5576
IS - 5
ER -