Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia

Viola C. Scoffone, Francesca Spadaro, Claudia Udine, Vadim Makarov, Marco Fondi, Renato Fani, Edda De Rossi, Giovanna Riccardi, Silvia Buroni

Research output: Contribution to journalArticle

Abstract

The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance- nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance.

Original languageEnglish
Pages (from-to)2415-2417
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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