Mechanisms and pathology of occupational asthma

C. E. Mapp, M. Saetta, P. Maestrelli, A. Di Stefano, P. Chitano, P. Boschetto, A. Ciaccia, L. M. Fabbri

Research output: Contribution to journalArticlepeer-review


Since the pathogenesis and the pathological features of occupational asthma are similar to those of nonoccupational asthma, the former represents a very useful model for the investigation of the pathogenesis of asthma in general. More than one mechanism may be operative in occupational asthma. Among the mechanisms proposed, immunological mechanisms and airway inflammation play an important role. There is evidence to confirm that T- lymphocyte activation and local accumulation in the bronchial wall of activated eosinophils occurs in asthma of diverse aetiology, i.e. immunoglobulin E (IgE)-mediated, occupational and intrinsic. Neurogenic pathways should be further investigated as a potential mechanism of modulation and amplification of airway inflammation in occupational asthma.

Original languageEnglish
Pages (from-to)544-554
Number of pages11
JournalEuropean Respiratory Journal
Issue number3
Publication statusPublished - 1994


  • Airway inflammation
  • asthma
  • immunity
  • workplace

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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