Mechanisms by which exercise training benefits patients with heart failure

Ettore Crimi, Louis J. Ignarro, Francesco Cacciatore, Claudio Napoli

Research output: Contribution to journalArticlepeer-review


Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of exercise tolerance. Regular exercise training is associated with health-improving effects. In patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and quality of life, as well as reduce hospitalization and, to some extent, risk of mortality. Progressive exercise training is associated with pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that increase oxygen delivery and energy production. This Review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on patients with heart failure.

Original languageEnglish
Pages (from-to)292-300
Number of pages9
JournalNature Reviews Cardiology
Issue number4
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


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