Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients

Giovanni Barisione, Andrea Bacigalupo, Claudia Brusasco, Chiara Scanarotti, Susanna Penco, Anna Maria Bassi, Teresa Lamparelli, Alessandro Garlaschi, Riccardo Pellegrino, Vito Brusasco

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lung diffusing capacity for CO (DLCO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (DM,CO) and pulmonary capillary volume (VC) from DLCO and diffusing capacity for NO (DLNO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DLNO and DLCO were significantly lower than in 30 healthy controls. DM,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DLNO and DM,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R2=0.71, pNO. We conclude that DLNO and, to a lesser extent, DLCO are compromised before HSCT mainly due to a DM,CO reduction. A further reduction of DM,CO without VC loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume194
Issue number1
DOIs
Publication statusPublished - Apr 1 2014

Fingerprint

Pulmonary Diffusing Capacity
Hematopoietic Stem Cell Transplantation
Carbon Monoxide
Lung Volume Measurements
Lung
Edema
Fibrosis
Oxygen
Membranes

Keywords

  • Alveolar-capillary membrane conductance
  • Carbon monoxide
  • Lung density
  • Nitric oxide
  • Pulmonary capillary volume
  • Reactive oxygen metabolites

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)
  • Medicine(all)

Cite this

Barisione, G., Bacigalupo, A., Brusasco, C., Scanarotti, C., Penco, S., Bassi, A. M., ... Brusasco, V. (2014). Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients. Respiratory Physiology and Neurobiology, 194(1), 54-61. https://doi.org/10.1016/j.resp.2014.01.018

Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients. / Barisione, Giovanni; Bacigalupo, Andrea; Brusasco, Claudia; Scanarotti, Chiara; Penco, Susanna; Bassi, Anna Maria; Lamparelli, Teresa; Garlaschi, Alessandro; Pellegrino, Riccardo; Brusasco, Vito.

In: Respiratory Physiology and Neurobiology, Vol. 194, No. 1, 01.04.2014, p. 54-61.

Research output: Contribution to journalArticle

Barisione, G, Bacigalupo, A, Brusasco, C, Scanarotti, C, Penco, S, Bassi, AM, Lamparelli, T, Garlaschi, A, Pellegrino, R & Brusasco, V 2014, 'Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients', Respiratory Physiology and Neurobiology, vol. 194, no. 1, pp. 54-61. https://doi.org/10.1016/j.resp.2014.01.018
Barisione, Giovanni ; Bacigalupo, Andrea ; Brusasco, Claudia ; Scanarotti, Chiara ; Penco, Susanna ; Bassi, Anna Maria ; Lamparelli, Teresa ; Garlaschi, Alessandro ; Pellegrino, Riccardo ; Brusasco, Vito. / Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients. In: Respiratory Physiology and Neurobiology. 2014 ; Vol. 194, No. 1. pp. 54-61.
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