Abstract
This study hypothesises that regardless of the global score of dyspnoea intensity, different descriptors may be selected by asthmatic patients during short cardiopulmonary exercise test (sCPET) and methacholine (Mch) inhalation. It also examines whether different qualitative dyspnoea sensations can help explain the underlying mechanisms of the symptom. Minute ventilation (V′ E), tidal volume (VT) and inspiratory capacity (IC) were measured in 22 stable asthmatic patients, and the sensation of dyspnoea during Mch inhalation and sCPET was quantitatively (Borg scale) and qualitatively (descriptors) assessed. The work rate and oxygen uptake (V′ O2) were also measured during sCPET. Airway obstruction and hyperinflation, as measured by IC reduction, were the best correlates for dyspnoea with Mch. During sCPET, changes in WR, V′ O2, V′ E and VT significantly correlated with Borg score, with V′ E being the best predictor of dyspnoea; IC decreased in eight patients. Furthermore, chest tightness (68%) was the highest reported descriptor during Mch inhalation, whereas work/effort (72%) was the highest during sCPET. In conclusion, obstruction/hyperinflation and work rate are highly reliable predictors of Borg rating of dyspnoea during methacholine inhalation and short cardiopulmonary exercise testing, respectively. Regardless of the global score of intensity dyspnoea, different descriptors may be selected by patients during short cardiopulmonary exercise testing and methacholine inhalation. Various qualities of dyspnoea result from different pathophysiological abnormalities.
| Original language | English |
|---|---|
| Pages (from-to) | 742-747 |
| Number of pages | 6 |
| Journal | European Respiratory Journal |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- Airway
- Asthma
- Dyspnoea
- Exercise
- Hyperinflation
- Methacholine
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Mechanisms of dyspnoea and its language in patients with asthma. / Laveneziana, P.; Lotti, P.; Coli, C.; Binazzi, B.; Chiti, L.; Stendardi, L.; Duranti, R.; Scano, G.
In: European Respiratory Journal, Vol. 27, No. 4, 04.2006, p. 742-747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of dyspnoea and its language in patients with asthma
AU - Laveneziana, P.
AU - Lotti, P.
AU - Coli, C.
AU - Binazzi, B.
AU - Chiti, L.
AU - Stendardi, L.
AU - Duranti, R.
AU - Scano, G.
PY - 2006/4
Y1 - 2006/4
N2 - This study hypothesises that regardless of the global score of dyspnoea intensity, different descriptors may be selected by asthmatic patients during short cardiopulmonary exercise test (sCPET) and methacholine (Mch) inhalation. It also examines whether different qualitative dyspnoea sensations can help explain the underlying mechanisms of the symptom. Minute ventilation (V′ E), tidal volume (VT) and inspiratory capacity (IC) were measured in 22 stable asthmatic patients, and the sensation of dyspnoea during Mch inhalation and sCPET was quantitatively (Borg scale) and qualitatively (descriptors) assessed. The work rate and oxygen uptake (V′ O2) were also measured during sCPET. Airway obstruction and hyperinflation, as measured by IC reduction, were the best correlates for dyspnoea with Mch. During sCPET, changes in WR, V′ O2, V′ E and VT significantly correlated with Borg score, with V′ E being the best predictor of dyspnoea; IC decreased in eight patients. Furthermore, chest tightness (68%) was the highest reported descriptor during Mch inhalation, whereas work/effort (72%) was the highest during sCPET. In conclusion, obstruction/hyperinflation and work rate are highly reliable predictors of Borg rating of dyspnoea during methacholine inhalation and short cardiopulmonary exercise testing, respectively. Regardless of the global score of intensity dyspnoea, different descriptors may be selected by patients during short cardiopulmonary exercise testing and methacholine inhalation. Various qualities of dyspnoea result from different pathophysiological abnormalities.
AB - This study hypothesises that regardless of the global score of dyspnoea intensity, different descriptors may be selected by asthmatic patients during short cardiopulmonary exercise test (sCPET) and methacholine (Mch) inhalation. It also examines whether different qualitative dyspnoea sensations can help explain the underlying mechanisms of the symptom. Minute ventilation (V′ E), tidal volume (VT) and inspiratory capacity (IC) were measured in 22 stable asthmatic patients, and the sensation of dyspnoea during Mch inhalation and sCPET was quantitatively (Borg scale) and qualitatively (descriptors) assessed. The work rate and oxygen uptake (V′ O2) were also measured during sCPET. Airway obstruction and hyperinflation, as measured by IC reduction, were the best correlates for dyspnoea with Mch. During sCPET, changes in WR, V′ O2, V′ E and VT significantly correlated with Borg score, with V′ E being the best predictor of dyspnoea; IC decreased in eight patients. Furthermore, chest tightness (68%) was the highest reported descriptor during Mch inhalation, whereas work/effort (72%) was the highest during sCPET. In conclusion, obstruction/hyperinflation and work rate are highly reliable predictors of Borg rating of dyspnoea during methacholine inhalation and short cardiopulmonary exercise testing, respectively. Regardless of the global score of intensity dyspnoea, different descriptors may be selected by patients during short cardiopulmonary exercise testing and methacholine inhalation. Various qualities of dyspnoea result from different pathophysiological abnormalities.
KW - Airway
KW - Asthma
KW - Dyspnoea
KW - Exercise
KW - Hyperinflation
KW - Methacholine
UR - http://www.scopus.com/inward/record.url?scp=33746648062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746648062&partnerID=8YFLogxK
U2 - 10.1183/09031936.06.00080505
DO - 10.1183/09031936.06.00080505
M3 - Article
VL - 27
SP - 742
EP - 747
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 4
ER -