Mechanisms of group B coxsackie virus persistence in human cells

M. Bendinelli, D. Matteucci, P. G. Conaldi, A. M. Giangregorio, M. R. Capobianchi, F. Dianzani

Research output: Contribution to journalArticlepeer-review

Abstract

Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalEuropean Heart Journal
Volume8
Issue numberSUPPL. J
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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