Mechanisms of group B coxsackie virus persistence in human cells

M. Bendinelli; D. Matteucci; P. G. Conaldi; A. M. Giangregorio; M. R. Capobianchi; F. Dianzani

Mechanisms of group B coxsackie virus persistence in human cells

M. Bendinelli, D. Matteucci, P. G. Conaldi, A. M. Giangregorio, M. R. Capobianchi, F. Dianzani

Research output: Contribution to journal › Article › peer-review

Abstract

Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.

Original language	English
Pages (from-to)	441-444
Number of pages	4
Journal	European Heart Journal
Volume	8
Issue number	SUPPL. J
Publication status	Published - 1987

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

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title = "Mechanisms of group B coxsackie virus persistence in human cells",

abstract = "Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.",

author = "M. Bendinelli and D. Matteucci and Conaldi, {P. G.} and Giangregorio, {A. M.} and Capobianchi, {M. R.} and F. Dianzani",

year = "1987",

language = "English",

volume = "8",

pages = "441--444",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "SUPPL. J",

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T1 - Mechanisms of group B coxsackie virus persistence in human cells

AU - Bendinelli, M.

AU - Matteucci, D.

AU - Conaldi, P. G.

AU - Giangregorio, A. M.

AU - Capobianchi, M. R.

AU - Dianzani, F.

PY - 1987

Y1 - 1987

N2 - Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.

AB - Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.

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M3 - Article

AN - SCOPUS:0023608660

VL - 8

SP - 441

EP - 444

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - SUPPL. J

ER -

Mechanisms of group B coxsackie virus persistence in human cells

Abstract

ASJC Scopus subject areas

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