Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoid cell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). The experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.
|Number of pages||4|
|Journal||European Heart Journal|
|Issue number||SUPPL. J|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine