Mechanisms of immune evasion of human neuroblastoma

Lizzia Raffaghello; Ignazia Prigione; Irma Airoldi; Marta Camoriano; Fabio Morandi; Paolo Bocca; Claudio Gambini; Soldano Ferrone; Vito Pistoia

doi:10.1016/j.canlet.2004.11.064

Mechanisms of immune evasion of human neuroblastoma

Lizzia Raffaghello, Ignazia Prigione, Irma Airoldi, Marta Camoriano, Fabio Morandi, Paolo Bocca, Claudio Gambini, Soldano Ferrone, Vito Pistoia

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Cancer Letters
Volume	228
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2004.11.064
Publication status	Published - Oct 18 2005

Keywords

Immunotherapy
Neuroblastoma
NK cells

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

Access to Document

10.1016/j.canlet.2004.11.064

Cite this

@article{972e4d31dcaa4ca9a9f09701d4d160eb,

title = "Mechanisms of immune evasion of human neuroblastoma",

abstract = "Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.",

keywords = "Immunotherapy, Neuroblastoma, NK cells",

author = "Lizzia Raffaghello and Ignazia Prigione and Irma Airoldi and Marta Camoriano and Fabio Morandi and Paolo Bocca and Claudio Gambini and Soldano Ferrone and Vito Pistoia",

year = "2005",

month = oct,

day = "18",

doi = "10.1016/j.canlet.2004.11.064",

language = "English",

volume = "228",

pages = "155--161",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Mechanisms of immune evasion of human neuroblastoma

AU - Raffaghello, Lizzia

AU - Prigione, Ignazia

AU - Airoldi, Irma

AU - Camoriano, Marta

AU - Morandi, Fabio

AU - Bocca, Paolo

AU - Gambini, Claudio

AU - Ferrone, Soldano

AU - Pistoia, Vito

PY - 2005/10/18

Y1 - 2005/10/18

N2 - Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

AB - Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

KW - Immunotherapy

KW - Neuroblastoma

KW - NK cells

UR - http://www.scopus.com/inward/record.url?scp=23944504734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944504734&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2004.11.064

DO - 10.1016/j.canlet.2004.11.064

M3 - Article

C2 - 15923080

AN - SCOPUS:23944504734

VL - 228

SP - 155

EP - 161

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1-2

ER -

Mechanisms of immune evasion of human neuroblastoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this