Mechanisms of immune evasion of human neuroblastoma

Lizzia Raffaghello, Ignazia Prigione, Irma Airoldi, Marta Camoriano, Fabio Morandi, Paolo Bocca, Claudio Gambini, Soldano Ferrone, Vito Pistoia

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalCancer Letters
Volume228
Issue number1-2
DOIs
Publication statusPublished - Oct 18 2005

Keywords

  • Immunotherapy
  • Neuroblastoma
  • NK cells

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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