Mechanisms of immune evasion of human neuroblastoma

Lizzia Raffaghello; Ignazia Prigione; Irma Airoldi; Marta Camoriano; Fabio Morandi; Paolo Bocca; Claudio Gambini; Soldano Ferrone; Vito Pistoia

doi:10.1016/j.canlet.2004.11.064

Mechanisms of immune evasion of human neuroblastoma

Lizzia Raffaghello, Ignazia Prigione, Irma Airoldi, Marta Camoriano, Fabio Morandi, Paolo Bocca, Claudio Gambini, Soldano Ferrone, Vito Pistoia

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Cancer Letters
Volume	228
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2004.11.064
Publication status	Published - Oct 18 2005

Keywords

Immunotherapy
Neuroblastoma
NK cells

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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abstract = "Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.",

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AU - Raffaghello, Lizzia

AU - Prigione, Ignazia

AU - Airoldi, Irma

AU - Camoriano, Marta

AU - Morandi, Fabio

AU - Bocca, Paolo

AU - Gambini, Claudio

AU - Ferrone, Soldano

AU - Pistoia, Vito

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AB - Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed.

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