Mechanisms of muscle growth and atrophy in mammals and Drosophila

Rosanna Piccirillo, Fabio Demontis, Norbert Perrimon, Alfred L. Goldberg

Research output: Contribution to journalArticle

Abstract

Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201-215, 2014.

Original languageEnglish
Pages (from-to)201-215
Number of pages15
JournalDevelopmental Dynamics
Volume243
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Animal models of muscle wasting
  • Muscle atrophy
  • Proteostasis
  • Skeletal muscle growth

ASJC Scopus subject areas

  • Developmental Biology

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