Meccanismi di protezione delle cellule miocardiche dal danno da ischemia/riperfusione e potenziali implicazioni terapeutiche

Translated title of the contribution: Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential therapeutic implications

Priscilla Lamendola, Antonio Di Monaco, Lucy Barone, Chiara Pisanello, Gaetano A. Lanza, Filippo Crea

Research output: Contribution to journalArticlepeer-review

Abstract

Myocardial cell damage caused by myocardial ischemia results from several factors that include the duration of ischemia, oxygen demand by cardiomyocytes at the time of ischemia, and the presence and entity of collateral blood flow to the ischemic area. Importantly, myocardial cell injury may derive not only from ischemia itself but also from detrimental phenomena occurring during the restoration of myocardial blood flow after the ischemic episode (reperfusion damage). In the last decades a lot of studies have demonstrated that cardiomyocytes have several mechanisms that provide them protection against the damage deriving from ischemia-reperfusion, also allowing a prolongation of survival in the most severe cases. In this article we review some of these mechanisms, also discussing their present and/or potential therapeutic applications in the clinical setting. The topics include the interventions aimed at reducing cardiac work through a reduction of oxygen demand by myocardial cells or at optimizing the utilization of energetic resources by myocardial cells in situations of ischemia, the importance of phenomena such as ischemic preconditioning (early and delayed) and postconditioning of myocardial cells, and, finally, the theoretic possibility of interventions aimed at preventing cell death consequent to apoptosis.

Translated title of the contributionMechanisms of myocardial cell protection from ischemia/reperfusion injury and potential therapeutic implications
Original languageItalian
Pages (from-to)28-36
Number of pages9
JournalGiornale Italiano di Cardiologia
Volume10
Issue number1
Publication statusPublished - Jan 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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