Mechanisms of obesity in the development of breast cancer

Stefania Orecchioni, Francesca Reggiani, Giovanna Talarico, Francesco Bertolini

Research output: Contribution to journalArticlepeer-review


Preclinical models and clinical retrospective data indicate that obesity is associated with a significant increase in the incidence, severity and mortality from different types of cancer, including postmenopausal breast cancer. As discussed in the present review, both soluble factors and cellular players are involved in the mechanisms promoting local and metastatic breast cancer progression by adipose tissue. As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalDiscovery medicine
Issue number109
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Medicine(all)


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