Mechanisms of periodic breathing during exercise in patients with chronic heart failure

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Periodic breathing (PB) in heart failure (HF) is attributed to many factors, including low cardiac output delaying the time it takes pulmonary venous blood to reach the central and peripheral chemoreceptors, low lung volume, lung congestion, augmented chemoreceptor sensitivity, and the narrow difference between eupneic carbon dioxide tension and apneic/hypoventilatory threshold. Methods and results: We measured expired gases, ventilation, amplitude, and duration of PB in 23 patients with PB during progressive exercise tests done with 0 mL, 250 mL, or 500 mL of added dead space. Periodicity of PB remained constant despite heart rate, oxygen consumption, and minute ventilation increasing. Within each PB cycle, starting from the beginning of exercise, the largest (peak) tidal volume approached maximum observed tidal volume, while the smallest (nadir) tidal volume increased as exercise power output increased. PB ceased when nadir tidal volume reached peak tidal volume. End-tidal carbon dioxide increased with added dead space, and PB ceased progressively earlier during the exercise done with increased dead space. Conclusion: Circulatory delay does not contribute to the PB observed in exercising HF patients. The pattern of gradually increasing nadir tidal volume during exercise and the effect of dead space on both PB ceasing and end-tidal carbon dioxide suggest that low tidal volume and carbon dioxide apnea threshold are important contributors to PB that occurs during exercise in HF.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalChest
Volume133
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Breathing Exercises
Respiration
Tidal Volume
Heart Failure
Carbon Dioxide
Exercise
Lung
Ventilation
Low Cardiac Output
Periodicity
Apnea
Exercise Test
Oxygen Consumption
Heart Rate
Gases

Keywords

  • Exercise
  • Heart failure
  • Periodic breathing

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mechanisms of periodic breathing during exercise in patients with chronic heart failure. / Agostoni, Piergiuseppe; Apostolo, Anna; Albert, Richard K.

In: Chest, Vol. 133, No. 1, 01.2008, p. 197-203.

Research output: Contribution to journalArticle

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N2 - Background: Periodic breathing (PB) in heart failure (HF) is attributed to many factors, including low cardiac output delaying the time it takes pulmonary venous blood to reach the central and peripheral chemoreceptors, low lung volume, lung congestion, augmented chemoreceptor sensitivity, and the narrow difference between eupneic carbon dioxide tension and apneic/hypoventilatory threshold. Methods and results: We measured expired gases, ventilation, amplitude, and duration of PB in 23 patients with PB during progressive exercise tests done with 0 mL, 250 mL, or 500 mL of added dead space. Periodicity of PB remained constant despite heart rate, oxygen consumption, and minute ventilation increasing. Within each PB cycle, starting from the beginning of exercise, the largest (peak) tidal volume approached maximum observed tidal volume, while the smallest (nadir) tidal volume increased as exercise power output increased. PB ceased when nadir tidal volume reached peak tidal volume. End-tidal carbon dioxide increased with added dead space, and PB ceased progressively earlier during the exercise done with increased dead space. Conclusion: Circulatory delay does not contribute to the PB observed in exercising HF patients. The pattern of gradually increasing nadir tidal volume during exercise and the effect of dead space on both PB ceasing and end-tidal carbon dioxide suggest that low tidal volume and carbon dioxide apnea threshold are important contributors to PB that occurs during exercise in HF.

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