Mechanisms of rule acquisition and rule following in inductive reasoning

Cristiano Crescentini, Shima Seyed-Allaei, Nicola de Pisapia, Jorge Jovicich, Daniele Amati, Tim Shallice

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Despite the recent interest in the neuroanatomy of inductive reasoning processes, the regional specificity within prefrontal cortex (PFC) for the different mechanisms involved in induction tasks remains to be determined. In this study, we used fMRI to investigate the contribution of PFC regions to rule acquisition (rule search and rule discovery) and rule following. Twenty-six healthy young adult participants were presented with a series of images of cards, each consisting of a set of circles numbered in sequence with one colored blue. Participants had to predict the position of the blue circle on the next card. The rules that had to be acquired pertained to the relationship among succeeding stimuli. Responses given by subjects were categorized in a series of phases either tapping rule acquisition (responses given up to and including rule discovery) or rule following (correct responses after rule acquisition). Mid-dorsolateral PFC (mid-DLPFC) was active during rule search and remained active until successful rule acquisition. By contrast, rule following was associated with activation in temporal, motor, and medial/anterior prefrontal cortex. Moreover, frontopolar cortex (FPC) was active throughout the rule acquisition and rule following phases before a rule became familiar. We attributed activation in mid-DLPFC to hypothesis generation and in FPC to integration of multiple separate inferences. The present study provides evidence that brain activation during inductive reasoning involves a complex network of frontal processes and that different subregions respond during rule acquisition and rule following phases.

Original languageEnglish
Pages (from-to)7763-7774
Number of pages12
JournalJournal of Neuroscience
Volume31
Issue number21
DOIs
Publication statusPublished - May 25 2011

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Prefrontal Cortex
Neuroanatomy
Young Adult
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

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Crescentini, C., Seyed-Allaei, S., de Pisapia, N., Jovicich, J., Amati, D., & Shallice, T. (2011). Mechanisms of rule acquisition and rule following in inductive reasoning. Journal of Neuroscience, 31(21), 7763-7774. https://doi.org/10.1523/JNEUROSCI.4579-10.2011

Mechanisms of rule acquisition and rule following in inductive reasoning. / Crescentini, Cristiano; Seyed-Allaei, Shima; de Pisapia, Nicola; Jovicich, Jorge; Amati, Daniele; Shallice, Tim.

In: Journal of Neuroscience, Vol. 31, No. 21, 25.05.2011, p. 7763-7774.

Research output: Contribution to journalArticle

Crescentini, C, Seyed-Allaei, S, de Pisapia, N, Jovicich, J, Amati, D & Shallice, T 2011, 'Mechanisms of rule acquisition and rule following in inductive reasoning', Journal of Neuroscience, vol. 31, no. 21, pp. 7763-7774. https://doi.org/10.1523/JNEUROSCI.4579-10.2011
Crescentini C, Seyed-Allaei S, de Pisapia N, Jovicich J, Amati D, Shallice T. Mechanisms of rule acquisition and rule following in inductive reasoning. Journal of Neuroscience. 2011 May 25;31(21):7763-7774. https://doi.org/10.1523/JNEUROSCI.4579-10.2011
Crescentini, Cristiano ; Seyed-Allaei, Shima ; de Pisapia, Nicola ; Jovicich, Jorge ; Amati, Daniele ; Shallice, Tim. / Mechanisms of rule acquisition and rule following in inductive reasoning. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 21. pp. 7763-7774.
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