Mechanisms of systemic vasculitis

Angelo A. Manfredi, Maria Grazia Sabbadini, Luca Ferri, Marco E. Bianchi, Patrizia Rovere-Querini

Research output: Contribution to journalArticle

Abstract

Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number3
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Systemic Vasculitis
Vasculitis
Blood Vessels
Leukocytes
Veins
Arteries
Inflammation

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Mechanisms of systemic vasculitis. / Manfredi, Angelo A.; Sabbadini, Maria Grazia; Ferri, Luca; Bianchi, Marco E.; Rovere-Querini, Patrizia.

In: Drug Discovery Today: Disease Mechanisms, Vol. 1, No. 3, 12.2004, p. 297-302.

Research output: Contribution to journalArticle

@article{1439bd62ed074febb6e1ada84fe27c73,
title = "Mechanisms of systemic vasculitis",
abstract = "Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.",
author = "Manfredi, {Angelo A.} and Sabbadini, {Maria Grazia} and Luca Ferri and Bianchi, {Marco E.} and Patrizia Rovere-Querini",
year = "2004",
month = "12",
doi = "10.1016/j.ddmec.2004.11.010",
language = "English",
volume = "1",
pages = "297--302",
journal = "Drug Discovery Today: Disease Mechanisms",
issn = "1740-6765",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Mechanisms of systemic vasculitis

AU - Manfredi, Angelo A.

AU - Sabbadini, Maria Grazia

AU - Ferri, Luca

AU - Bianchi, Marco E.

AU - Rovere-Querini, Patrizia

PY - 2004/12

Y1 - 2004/12

N2 - Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.

AB - Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.

UR - http://www.scopus.com/inward/record.url?scp=23744504994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744504994&partnerID=8YFLogxK

U2 - 10.1016/j.ddmec.2004.11.010

DO - 10.1016/j.ddmec.2004.11.010

M3 - Article

AN - SCOPUS:23744504994

VL - 1

SP - 297

EP - 302

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

SN - 1740-6765

IS - 3

ER -