Mechanisms of thrombin-induced modifications of human platelet cytoskeleton

F. Sinigaglia, C. L. Balduini, A. Bisio, C. Balduini

Research output: Contribution to journalArticlepeer-review

Abstract

1. Thrombin treated with phenylmethanesulphonyl fluoride, like active enzyme, promotes modifications to human platelet cytoskeleton. 2. The removal of active thrombin by hirudin partially reverses this process. 3. Chymotrypsin-treated platelets do not modify their cytoskeleton after thrombin stimulus, but are still able to increase their adhesiveness to collagen. It is concluded that thrombin influences the cytoskeleton and adhesion by non-enzymic mechanisms which may be mediated by different modulators.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalBiochemical Journal
Volume232
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Biochemistry

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