Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy

Angela Santoni, Claudia Carlino, Helena Stabile, Angela Gismondi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Natural killer (NK) cells represent the most prominent immune cell type found in the uterus in the first trimester of human pregnancy and in the secretory phase of menstrual cycle. The role of NK cells in pregnancy has been largely discussed over the past years and it is now becoming increasingly clear that they may influence pregnancy outcome at several levels. In normal pregnancy, it appears that the major function of NK cells is to provide benefit by secreting a number of cytokines, chemokines and angiogenic factors rather than to exert a cytotoxic activity. However, the origin of decidual NK cells is still debated and it remains unclear whether they can derive from NK cell populations recruited from peripheral blood and/or other tissues or from self renewal of NK cell progenitors present in the uterus prior to pregnancy or recruited from other tissues. Here, we review the molecular mechanisms underlying peripheral blood NK cell recruitment and its role in the accumulation of NK cells in the decidua during early pregnancy.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalAmerican Journal of Reproductive Immunology
Volume59
Issue number5
DOIs
Publication statusPublished - May 2008

Fingerprint

Natural Killer Cells
Uterus
Pregnancy
Decidua
Angiogenesis Inducing Agents
Luteal Phase
First Pregnancy Trimester
Pregnancy Outcome
Chemokines
Blood Cells
Cytokines
Population

Keywords

  • Adhesion molecules
  • Chemokines
  • Decidual endothelial cells
  • Decidual stromal cells
  • NK cell migration
  • Uterine NK cells

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy. / Santoni, Angela; Carlino, Claudia; Stabile, Helena; Gismondi, Angela.

In: American Journal of Reproductive Immunology, Vol. 59, No. 5, 05.2008, p. 417-424.

Research output: Contribution to journalArticle

Santoni, Angela ; Carlino, Claudia ; Stabile, Helena ; Gismondi, Angela. / Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy. In: American Journal of Reproductive Immunology. 2008 ; Vol. 59, No. 5. pp. 417-424.
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