Abstract
The hemodynamic changes induced by coronary occlusion were investigated in anesthetized dogs. Coronary occlusion elicited an immediate but transient increase in the systemic blood pressure and in the vascular resistance of the hind limb perfused at constant flow. Thereafter, systemic hypotension and vasodilatation in the perfused region were observed. Vagotomy abolished the initial increase of the systemic and perfusion pressure and reduced significantly the late vasodilator response both systemically and in the perfused hind limb. After the subsequent administration of hexamethonium the vasodilatation in the hind limb was no longer manifest but the fall in blood pressure was unmodified. These results seem to suggest that multiple mechanisms are involved in the hemodynamic response to coronary occlusion.
| Original language | English |
|---|---|
| Pages (from-to) | 407-412 |
| Number of pages | 6 |
| Journal | Japanese Heart Journal |
| Volume | 22 |
| Issue number | 3 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Mechanisms underlying systemic hemodynamic responses to experimental coronary artery occlusion. A preliminary study with hexamethonium. / Trimarco, B.; Rengo, F.; Ricciardelli, B.; Volpe, M.; Saccá, L.; De Simone, A.; Condorelli, M.
In: Japanese Heart Journal, Vol. 22, No. 3, 1981, p. 407-412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms underlying systemic hemodynamic responses to experimental coronary artery occlusion. A preliminary study with hexamethonium
AU - Trimarco, B.
AU - Rengo, F.
AU - Ricciardelli, B.
AU - Volpe, M.
AU - Saccá, L.
AU - De Simone, A.
AU - Condorelli, M.
PY - 1981
Y1 - 1981
N2 - The hemodynamic changes induced by coronary occlusion were investigated in anesthetized dogs. Coronary occlusion elicited an immediate but transient increase in the systemic blood pressure and in the vascular resistance of the hind limb perfused at constant flow. Thereafter, systemic hypotension and vasodilatation in the perfused region were observed. Vagotomy abolished the initial increase of the systemic and perfusion pressure and reduced significantly the late vasodilator response both systemically and in the perfused hind limb. After the subsequent administration of hexamethonium the vasodilatation in the hind limb was no longer manifest but the fall in blood pressure was unmodified. These results seem to suggest that multiple mechanisms are involved in the hemodynamic response to coronary occlusion.
AB - The hemodynamic changes induced by coronary occlusion were investigated in anesthetized dogs. Coronary occlusion elicited an immediate but transient increase in the systemic blood pressure and in the vascular resistance of the hind limb perfused at constant flow. Thereafter, systemic hypotension and vasodilatation in the perfused region were observed. Vagotomy abolished the initial increase of the systemic and perfusion pressure and reduced significantly the late vasodilator response both systemically and in the perfused hind limb. After the subsequent administration of hexamethonium the vasodilatation in the hind limb was no longer manifest but the fall in blood pressure was unmodified. These results seem to suggest that multiple mechanisms are involved in the hemodynamic response to coronary occlusion.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019442577&partnerID=8YFLogxK
M3 - Article
VL - 22
SP - 407
EP - 412
JO - Japanese Heart Journal
JF - Japanese Heart Journal
SN - 0021-4868
IS - 3
ER -