Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: An in vivo study

Umberto Morbiducci, Raffaele Ponzini, Giovanna Rizzo, Marcello Cadioli, Antonio Esposito, Franco Maria Montevecchi, Alberto Redaelli

Research output: Contribution to journalArticlepeer-review

Abstract

The hemodynamics within the aorta of five healthy humans were investigated to gain insight into the complex helical flow patterns that arise from the existence of asymmetries in the aortic region. The adopted approach is aimed at (1) overcoming the relative paucity of quantitative data regarding helical blood flow dynamics in the human aorta and (2) identifying common characteristics in physiological aortic flow topology, in terms of its helical content. Four-dimensional phase-contrast magnetic resonance imaging (4D PC MRI) was combined with algorithms for the calculation of advanced fluid dynamics in this study. These algorithms allowed us to obtain a 4D representation of intra-aortic flow fields and to quantify the aortic helical flow. For our purposes, helicity was used as a measure of the alignment of the velocity and the vorticity. There were two key findings of our study: (1) intra-individual analysis revealed a statistically significant difference in the helical content at different phases of systole and (2) group analysis suggested that aortic helical blood flow dynamics is an emerging behavior that is common to normal individuals. Our results also suggest that helical flow might be caused by natural optimization of fluid transport processes in the cardiovascular system, aimed at obtaining efficient perfusion. The approach here applied to assess in vivo helical blood flow could be the starting point to elucidate the role played by helicity in the generation and decay of rotating flows in the thoracic aorta.

Original languageEnglish
Pages (from-to)339-355
Number of pages17
JournalBiomechanics and Modeling in Mechanobiology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • 4D phase-contrast MRI
  • Aortic arch
  • Fluid mechanics
  • Hemodynamics
  • Perfusion
  • Spiral flow

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modelling and Simulation

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