Mechanochemistry: targeted delivery of single molecules.

Anne Sophie Duwez, Stéphane Cuenot, Christine Jérôme, Sabine Gabriel, Robert Jérôme, Stefania Rapino, Francesco Zerbetto

Research output: Contribution to journalArticlepeer-review


The use of scanning probe microscopy-based techniques to manipulate single molecules and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological challenge. The ultimate physical limit in the design and fabrication of organic surfaces can be reached using this approach. Here we show that the atomic force microscope (AFM), which has been used extensively to investigate the stretching of individual molecules, can deliver and immobilize single molecules, one at a time, on a surface. Reactive polymer molecules, attached at one end to an AFM tip, are brought into contact with a modified silicon substrate to which they become linked by a chemical reaction. When the AFM tip is pulled away from the surface, the resulting mechanical force causes the weakest bond - the one between the tip and polymer - to break. This process transfers the polymer molecule to the substrate where it can be modified by further chemical reactions.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalNature Nanotechnology
Issue number2
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics


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