Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment

C. Geroldi, R. Rossi, C. Calvagna, C. Testa, L. Bresciani, G. Binetti, O. Zanetti, G. B. Frisoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The diagnosis of mild cognitive impairment (MCI) is clinically unhelpful, as many patients with MCI develop dementia but many do not. Objective: To identify clinical instruments easily applicable in the clinical routine that might be useful to predict progression to dementia in patients with MCI assessed in the outpatient facility of a memory clinic. Participants and methods: 52 dementia-free patients (mean (standard deviation) age 70 (6) years; 56% women) with MCI, and 65 healthy controls (age 69 (6) years; 54% women) underwent brain magnetic resonance scan with standardised visual assessment of medial temporal atrophy (MTA) and subcortical cerebrovascular lesions (SVLs). Follow-up assessment occurred 15.4 (SD 3.4) months after baseline to detect incident dementia and improvement, defined as normal neuropsychological performance on follow-up. Results: Patients were classified into three groups according to the presence of memory disturbance only (MCI Mem), other neuropsychological deficits (MCI Oth) or both (MCI Mem+). MCI Mem and Mem+ showed MTA more frequently (31% and 47% v 5% and 14% of controls and MCI Oth, p

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number11
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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