Mediastinal Germ Cell Tumors in Pediatric Patients: A Report From the Italian Association of Pediatric Hematology and Oncology

Maria Debora De Pasquale, Alessandro Crocoli, Massimo Conte, Paolo Indolfi, P. D'Angelo, Renata Boldrini, Monica Terenziani, Alessandro Inserra

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Primary mediastinal germ cell tumors (GCTs) are rare in children and still represent a challenge for both adult and pediatric oncologists because of their worse outcome compared to their gonadal counterpart.

PROCEDURE: Prospectively collected data concerning patients enrolled in the Italian Association of Pediatric Haematology and Oncology study on malignant GCTs (AIEOP TCGM 2004) protocol for the treatment of GCTs were analyzed. Patients with malignant mediastinal primary GCTs were included in this study. Data regarding patients with newly diagnosed mediastinal teratoma were also collected.

RESULTS: From 2005 to 2013, 20 children diagnosed with mediastinal GCTs were registered in AIEOP TCGM 2004 protocol. With a median follow-up of 89 months (range 35-123), the overall survival (OS) and event free survival (EFS) rates were 100% for teratoma and 90% for malignant GCTs.

CONCLUSIONS: We confirm the favorable outcome of children affected by mediastinal teratoma and malignant GCTs. For malignant tumors, further studies on the clinical characteristics and genetic signatures on tumor samples might be necessary to better understand differences observed in high-risk patients and to assist the development of more effective treatment for this subgroup.

Original languageEnglish
Pages (from-to)808-812
Number of pages5
JournalPediatric Blood and Cancer
Volume63
Issue number5
DOIs
Publication statusPublished - May 1 2016

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Germ Cell and Embryonal Neoplasms
Hematology
Pediatrics
Teratoma
Clinical Protocols
Disease-Free Survival
Neoplasms
Survival Rate
Survival

Keywords

  • childhood
  • germ cell tumors
  • malignancies
  • mediastinal tumors
  • teratoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mediastinal Germ Cell Tumors in Pediatric Patients : A Report From the Italian Association of Pediatric Hematology and Oncology. / De Pasquale, Maria Debora; Crocoli, Alessandro; Conte, Massimo; Indolfi, Paolo; D'Angelo, P.; Boldrini, Renata; Terenziani, Monica; Inserra, Alessandro.

In: Pediatric Blood and Cancer, Vol. 63, No. 5, 01.05.2016, p. 808-812.

Research output: Contribution to journalArticle

De Pasquale, MD, Crocoli, A, Conte, M, Indolfi, P, D'Angelo, P, Boldrini, R, Terenziani, M & Inserra, A 2016, 'Mediastinal Germ Cell Tumors in Pediatric Patients: A Report From the Italian Association of Pediatric Hematology and Oncology', Pediatric Blood and Cancer, vol. 63, no. 5, pp. 808-812. https://doi.org/10.1002/pbc.25895
De Pasquale, Maria Debora ; Crocoli, Alessandro ; Conte, Massimo ; Indolfi, Paolo ; D'Angelo, P. ; Boldrini, Renata ; Terenziani, Monica ; Inserra, Alessandro. / Mediastinal Germ Cell Tumors in Pediatric Patients : A Report From the Italian Association of Pediatric Hematology and Oncology. In: Pediatric Blood and Cancer. 2016 ; Vol. 63, No. 5. pp. 808-812.
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