Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement

M. Froldi, A. Castagna, M. Parma, A. Piona, A. Tedeschi, A. Miadonna, M. Lorini, E. Nobile Orazio, A. Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we evaluated the release of some mediators of inflammatory reactions such as histamine (H), leukotriene B4 (LTB4) leukotriene C4 (LTC4) and prostaglandin D2 (PGD2) in the cerebrospinal fluid (CSF) of 15 patients with acquired immunodeficiency syndrome (AIDS), eight with opportunistic infections of the central nervous system (CNS) and seven without HIV-related neurological pathology, and of 25 HIV-negative control subjects with other neurological diseases. The cerebrospinal LTB4 level was increased in all the AIDS patients (mean 348 pg/ml); the control group revealed normal levels of LTB4 in the CSF (mean 63.2 pg/ml). The PGD2 level in the HIV-positive (mean 264 pg/ml) patients was higher than of the control subjects (mean 50 pg/ml), while low LTC4 levels were found both in the HIV-positive and control groups. We did not find any significant concentration of H in the CSF of either the HIV-positive or the control subjects. These findings may be due to the presence of chronic HIV infection or to the opportunistic infections of the CNS that so often occur in the latest stages of the disease.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalJournal of Neuroimmunology
Volume38
Issue number1-2
DOIs
Publication statusPublished - 1992

Keywords

  • Cerebrospinal fluid
  • Human immunodeficiency virus
  • Leukotriene B

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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