Mediators and allergic inflammation of human airways

A. Miadonna, A. Tedeschi, E. Leggieri, C. Brasca, G. C. Folco, A. Sola, M. Froldi, C. Zanussi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Local antigen challenge in patients with respiratory allergy is associated with histamine and arachidonic acid metabolites release, both in upper and in lower respiratory airways. Raised histamine levels can be detected in nasal secretions 5 min after allergen stimulation. Increased leukotriene C4 and prostaglandin D2 concentrations persist for a longer period (respectively 20 and 30 min). Endobronchial antigen stimulation is also followed by release of histamine, leukotriene C4 and prostaglandin D2, which can be detected in bronchial lavage fluid. Elevated concentrations of these mediators can be found 5 and 15 min after challenge. Moreover, endobronchial antigen stimulation is associated with an increase in the number of bronchial epithelial cells recovered in bronchial lavage fluids.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalRespiration
Volume54
DOIs
Publication statusPublished - 1988

Fingerprint

Inflammation Mediators
Prostaglandin D2
Leukotriene C4
Bronchoalveolar Lavage Fluid
Antigens
Histamine
Histamine Release
Nose
Arachidonic Acid
Allergens
Hypersensitivity
Epithelial Cells

Keywords

  • Antigen challenge
  • Histamine
  • Leukotriene C<inf>4</inf>
  • Prostaglandin D<inf>2</inf>
  • Respiratory allergy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Miadonna, A., Tedeschi, A., Leggieri, E., Brasca, C., Folco, G. C., Sola, A., ... Zanussi, C. (1988). Mediators and allergic inflammation of human airways. Respiration, 54, 78-83. https://doi.org/10.1159/000195481

Mediators and allergic inflammation of human airways. / Miadonna, A.; Tedeschi, A.; Leggieri, E.; Brasca, C.; Folco, G. C.; Sola, A.; Froldi, M.; Zanussi, C.

In: Respiration, Vol. 54, 1988, p. 78-83.

Research output: Contribution to journalArticle

Miadonna, A, Tedeschi, A, Leggieri, E, Brasca, C, Folco, GC, Sola, A, Froldi, M & Zanussi, C 1988, 'Mediators and allergic inflammation of human airways', Respiration, vol. 54, pp. 78-83. https://doi.org/10.1159/000195481
Miadonna A, Tedeschi A, Leggieri E, Brasca C, Folco GC, Sola A et al. Mediators and allergic inflammation of human airways. Respiration. 1988;54:78-83. https://doi.org/10.1159/000195481
Miadonna, A. ; Tedeschi, A. ; Leggieri, E. ; Brasca, C. ; Folco, G. C. ; Sola, A. ; Froldi, M. ; Zanussi, C. / Mediators and allergic inflammation of human airways. In: Respiration. 1988 ; Vol. 54. pp. 78-83.
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