Medical grade calcium sulfate hemihydrate in healing of human extraction sockets: Clinical and histological observations at 3 months

Renzo Guarnieri, Gabriele Pecora, Milena Fini, Nicolo' Nicoli Aldini, Roberto Giardino, Giovanna Orsini, Adriano Piattelli

Research output: Contribution to journalArticlepeer-review


Background: Following tooth extraction, remodeling and resorption of the alveolar bone at the extraction site characterize wound healing. This produces a reduction in ridge volume and difficulties in delayed placement of implants in an ideal position. Medical grade calcium sulfate hemihydrate (MGCSH) has been proposed as a graft material in extraction sockets to minimize the reduction in ridge volume. The aim of the present study was to investigate the influence of MGCSH on the histopathologic pattern of intrasocket regenerated bone and to evaluate histologically the healed MGCSH grafted extraction socket site 3 months postextraction Methods: MGCSH was grafted in 10 fresh human extraction sockets in 10 patients. Five post-extraction sockets were used as controls. At 3 months a cylindrical tissue specimen, 2.5 mm in diameter, was trephined from the previously grafted site followed by implant placement. Non-decalcified specimens were sectioned at a cross-horizontal plane and stained with fast green, toluidine blue, and Van Kossa stains for histological and histomorphometrical examination. Results: Histologically, MGCSH was not observed in most of the specimens. Newly formed bone with lamellar arrangements was identified in all the horizontal sections with no difference between apical, medium, and coronal areas. The mean trabecular area in the coronal sections was 58.6% ± 9.2%; in the medium sections, 58.1% ± 6.2%; and in the apical sections, 58.3% ± 7.8%. The differences were not statistically significant. Conclusion: MGCSH seems to be an ideal graft material in extraction socket bone regeneration because it is almost completely resorbable, and it allows a new trabecular bone arrangement at 3 months.

Original languageEnglish
Pages (from-to)902-908
Number of pages7
JournalJournal of Periodontology
Issue number6
Publication statusPublished - Jun 2004


  • Alveolar bone loss/prevention and control
  • Bone regeneration
  • Calcium sulfate/therapeutic use
  • Gratfs
  • Tooth extraction
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)


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