Medical management of endometriosis

Luigi Fedele, Stefano Blanchi, Eleonora Fontana, Nicola Berlanda, Giada Frontino, Alessandro Bulfoni

Research output: Contribution to journalArticlepeer-review

Abstract

Current approved medical therapies for endometriosis rely on drugs that suppress ovarian steroids and induce a hypoestrogenic state, which determines the atrophy of the ectopic endometrium. Gonadotropin-releasing hormone analogs such as danazol, progestogens and estrogen-progestin combinations have all proven effective in relieving pain and reducing the extent of endometriotic implants. However, symptoms often recur after discontinuation of therapy and hypoestrogenism-related side effects limit the long-term use of most medications. Recently, knowledge of the pathogenesis of endometriosis, particularly at the molecular level, has grown substantially, providing a rational basis for the development of new drugs with precise targets that may be safely administered over the long term.

Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalWomen's Health
Volume2
Issue number2
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Amenorrhea
  • Dysmenorrhea
  • Dyspareunia
  • Endometriosis
  • Hormonal treatment
  • Medical treatment
  • Pelvic pain

ASJC Scopus subject areas

  • Medicine(all)

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