Medical therapy of pancreatic neuroendocrine neoplasms

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic neuroendocrine neoplasms (PNENs) are most commonly advanced, low/intermediate-grade of malignancy, nonfunctioning, and somatostatin receptor expressing. However in a small percentage of cases, they are high-grade of malignancy, and prognosis is poor independently from therapy. Medical therapy of PNENs is usually considered in advanced stage of disease. It should be based on the right diagnosis, prognostic estimate, and morphological and functional characterization of disease. Several different options can be considered, including chemotherapy, somatostatin analogs, interferon, molecular-targeted agents, peptide receptor radionuclide therapy, and liver-directed treatments. While in high-grade PNENs, chemotherapy represents the only therapeutic option; in low-/intermediate-grade PNENs, several options should be discussed within a multidisciplinary team. No studies defining sequence, timing, and integration of the different therapies exist so far; therefore, a specific therapeutic strategy for the single patient should be discussed and shared by means of an interactive interdisciplinary discussion, preferably involving a referral center for NEN.

Original languageEnglish
Title of host publicationPancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy
PublisherSpringer International Publishing
Pages191-195
Number of pages5
ISBN (Print)9783319172354, 9783319172347
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Chemotherapy
Pancreatic Neoplasms
Somatostatin Receptors
Peptide Receptors
Somatostatin
Radioisotopes
Liver
Interferons
Therapeutics
Drug Therapy
Neoplasms
Referral and Consultation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fazio, N. (2015). Medical therapy of pancreatic neuroendocrine neoplasms. In Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy (pp. 191-195). Springer International Publishing. https://doi.org/10.1007/978-3-319-17235-4_22

Medical therapy of pancreatic neuroendocrine neoplasms. / Fazio, Nicola.

Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy. Springer International Publishing, 2015. p. 191-195.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fazio, N 2015, Medical therapy of pancreatic neuroendocrine neoplasms. in Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy. Springer International Publishing, pp. 191-195. https://doi.org/10.1007/978-3-319-17235-4_22
Fazio N. Medical therapy of pancreatic neuroendocrine neoplasms. In Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy. Springer International Publishing. 2015. p. 191-195 https://doi.org/10.1007/978-3-319-17235-4_22
Fazio, Nicola. / Medical therapy of pancreatic neuroendocrine neoplasms. Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy. Springer International Publishing, 2015. pp. 191-195
@inbook{89534698b045466a8b94271d97038eed,
title = "Medical therapy of pancreatic neuroendocrine neoplasms",
abstract = "Pancreatic neuroendocrine neoplasms (PNENs) are most commonly advanced, low/intermediate-grade of malignancy, nonfunctioning, and somatostatin receptor expressing. However in a small percentage of cases, they are high-grade of malignancy, and prognosis is poor independently from therapy. Medical therapy of PNENs is usually considered in advanced stage of disease. It should be based on the right diagnosis, prognostic estimate, and morphological and functional characterization of disease. Several different options can be considered, including chemotherapy, somatostatin analogs, interferon, molecular-targeted agents, peptide receptor radionuclide therapy, and liver-directed treatments. While in high-grade PNENs, chemotherapy represents the only therapeutic option; in low-/intermediate-grade PNENs, several options should be discussed within a multidisciplinary team. No studies defining sequence, timing, and integration of the different therapies exist so far; therefore, a specific therapeutic strategy for the single patient should be discussed and shared by means of an interactive interdisciplinary discussion, preferably involving a referral center for NEN.",
author = "Nicola Fazio",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-17235-4_22",
language = "English",
isbn = "9783319172354",
pages = "191--195",
booktitle = "Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Medical therapy of pancreatic neuroendocrine neoplasms

AU - Fazio, Nicola

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Pancreatic neuroendocrine neoplasms (PNENs) are most commonly advanced, low/intermediate-grade of malignancy, nonfunctioning, and somatostatin receptor expressing. However in a small percentage of cases, they are high-grade of malignancy, and prognosis is poor independently from therapy. Medical therapy of PNENs is usually considered in advanced stage of disease. It should be based on the right diagnosis, prognostic estimate, and morphological and functional characterization of disease. Several different options can be considered, including chemotherapy, somatostatin analogs, interferon, molecular-targeted agents, peptide receptor radionuclide therapy, and liver-directed treatments. While in high-grade PNENs, chemotherapy represents the only therapeutic option; in low-/intermediate-grade PNENs, several options should be discussed within a multidisciplinary team. No studies defining sequence, timing, and integration of the different therapies exist so far; therefore, a specific therapeutic strategy for the single patient should be discussed and shared by means of an interactive interdisciplinary discussion, preferably involving a referral center for NEN.

AB - Pancreatic neuroendocrine neoplasms (PNENs) are most commonly advanced, low/intermediate-grade of malignancy, nonfunctioning, and somatostatin receptor expressing. However in a small percentage of cases, they are high-grade of malignancy, and prognosis is poor independently from therapy. Medical therapy of PNENs is usually considered in advanced stage of disease. It should be based on the right diagnosis, prognostic estimate, and morphological and functional characterization of disease. Several different options can be considered, including chemotherapy, somatostatin analogs, interferon, molecular-targeted agents, peptide receptor radionuclide therapy, and liver-directed treatments. While in high-grade PNENs, chemotherapy represents the only therapeutic option; in low-/intermediate-grade PNENs, several options should be discussed within a multidisciplinary team. No studies defining sequence, timing, and integration of the different therapies exist so far; therefore, a specific therapeutic strategy for the single patient should be discussed and shared by means of an interactive interdisciplinary discussion, preferably involving a referral center for NEN.

UR - http://www.scopus.com/inward/record.url?scp=84945121903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945121903&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-17235-4_22

DO - 10.1007/978-3-319-17235-4_22

M3 - Chapter

AN - SCOPUS:84945121903

SN - 9783319172354

SN - 9783319172347

SP - 191

EP - 195

BT - Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy

PB - Springer International Publishing

ER -