Abstract
Medication-overuse headache (MOH) is a clinically important entity and it is now well documented that the regular use of acute symptomatic medication by people with migraine or tension-type headache increases the risk of aggravation of the primary headache. MOH is one the most common causes of chronic migraine-like syndrome. In this article, we analyse the possible mechanisms that underlie sensitization in MOH by comparing these mechanisms with those reported for other forms of drug addiction. Moreover, the evidence for cognitive impulsivity in drug overuse in headache and in other forms of addiction associated with dysfunction of the frontostriatal system will be discussed. An integrative hypothesis for compulsive reward-seeking in MOH will be presented.
| Original language | English |
|---|---|
| Pages (from-to) | 62-68 |
| Number of pages | 7 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2005 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Medication-overuse headache : Similarities with drug addiction. / Calabresi, Paolo; Cupini, Letizia Maria.
In: Trends in Pharmacological Sciences, Vol. 26, No. 2, 02.2005, p. 62-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Medication-overuse headache
T2 - Similarities with drug addiction
AU - Calabresi, Paolo
AU - Cupini, Letizia Maria
PY - 2005/2
Y1 - 2005/2
N2 - Medication-overuse headache (MOH) is a clinically important entity and it is now well documented that the regular use of acute symptomatic medication by people with migraine or tension-type headache increases the risk of aggravation of the primary headache. MOH is one the most common causes of chronic migraine-like syndrome. In this article, we analyse the possible mechanisms that underlie sensitization in MOH by comparing these mechanisms with those reported for other forms of drug addiction. Moreover, the evidence for cognitive impulsivity in drug overuse in headache and in other forms of addiction associated with dysfunction of the frontostriatal system will be discussed. An integrative hypothesis for compulsive reward-seeking in MOH will be presented.
AB - Medication-overuse headache (MOH) is a clinically important entity and it is now well documented that the regular use of acute symptomatic medication by people with migraine or tension-type headache increases the risk of aggravation of the primary headache. MOH is one the most common causes of chronic migraine-like syndrome. In this article, we analyse the possible mechanisms that underlie sensitization in MOH by comparing these mechanisms with those reported for other forms of drug addiction. Moreover, the evidence for cognitive impulsivity in drug overuse in headache and in other forms of addiction associated with dysfunction of the frontostriatal system will be discussed. An integrative hypothesis for compulsive reward-seeking in MOH will be presented.
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UR - http://www.scopus.com/inward/citedby.url?scp=12844255912&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2004.12.008
DO - 10.1016/j.tips.2004.12.008
M3 - Article
VL - 26
SP - 62
EP - 68
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 2
ER -