Medio-dorsal thalamus and confabulations

Evidence from a clinical case and combined MRI/DTI study

Valeria Onofrj, Stefano Delli Pizzi, Raffaella Franciotti, John Paul Taylor, Bernardo Perfetti, Massimo Caulo, Marco Onofrj, Laura Bonanni

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The Medio-Dorsal Nuclei (MDN) including the thalamic magnocellular and parvocellular thalamic regions has been implicated in verbal memory function. In a 77 year old lady, with a prior history of a clinically silent infarct of the left MDN, we observed the acute onset of spontaneous confabulations when an isolated new infarct occurred in the right MDN. The patient and five age-matched healthy subjects underwent Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI). The thalamic lesions were localized by overlapping Morel Thalamic Atlas with structural MRI data. DTI was used to assess: i) white matter alterations (Fractional Anisotropy, FA) within fibers connecting the ischemic areas to cortex; ii) the micro-structural damage (Mean Diffusivity) within the thalamic sub-regions defined by their structural connectivity to the Anterior Cingulate Cortex (ACC) and to the temporal lobes. These target regions were chosen because their damage is considered associated with the appearance of confabulations. Thalamic lesions were localized within the parvocellular regions of the right and left MDNs. The structural connectivity study showed that the fiber tracts, connecting the bilaterally damaged thalamic regions with the frontal cortex, corresponded to the anterior thalamic radiations (ATR). FA within these tracts was significantly lower in the patient as compared to controls. Mean diffusivity within the MDNs projecting to Broadman area (BA) 24, BA25 and BA32 of ACC was significantly higher in the patient than in control group. Mean diffusivity values within the MDN projecting to temporal lobes in contrast were not different between patient and controls. Our findings suggest the involvement of bilateral MDNs projections to ACC in the genesis of confabulations and help provide clarity to the longstanding debate on the origin of confabulations.

Original languageEnglish
Pages (from-to)776-784
Number of pages9
JournalNeuroImage: Clinical
Volume12
DOIs
Publication statusPublished - 2016

Fingerprint

Diffusion Tensor Imaging
Thalamus
Gyrus Cinguli
Magnetic Resonance Imaging
Anisotropy
Temporal Lobe
Thalamic Nuclei
Atlases
Frontal Lobe
Healthy Volunteers
Radiation
Control Groups

Keywords

  • Amnesia
  • Confabulation
  • Medio-dorsal thalamic region

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Onofrj, V., Delli Pizzi, S., Franciotti, R., Taylor, J. P., Perfetti, B., Caulo, M., ... Bonanni, L. (2016). Medio-dorsal thalamus and confabulations: Evidence from a clinical case and combined MRI/DTI study. NeuroImage: Clinical, 12, 776-784. https://doi.org/10.1016/j.nicl.2016.10.011

Medio-dorsal thalamus and confabulations : Evidence from a clinical case and combined MRI/DTI study. / Onofrj, Valeria; Delli Pizzi, Stefano; Franciotti, Raffaella; Taylor, John Paul; Perfetti, Bernardo; Caulo, Massimo; Onofrj, Marco; Bonanni, Laura.

In: NeuroImage: Clinical, Vol. 12, 2016, p. 776-784.

Research output: Contribution to journalArticle

Onofrj, V, Delli Pizzi, S, Franciotti, R, Taylor, JP, Perfetti, B, Caulo, M, Onofrj, M & Bonanni, L 2016, 'Medio-dorsal thalamus and confabulations: Evidence from a clinical case and combined MRI/DTI study', NeuroImage: Clinical, vol. 12, pp. 776-784. https://doi.org/10.1016/j.nicl.2016.10.011
Onofrj, Valeria ; Delli Pizzi, Stefano ; Franciotti, Raffaella ; Taylor, John Paul ; Perfetti, Bernardo ; Caulo, Massimo ; Onofrj, Marco ; Bonanni, Laura. / Medio-dorsal thalamus and confabulations : Evidence from a clinical case and combined MRI/DTI study. In: NeuroImage: Clinical. 2016 ; Vol. 12. pp. 776-784.
@article{d44a471fae174adfad4f435b32d21af7,
title = "Medio-dorsal thalamus and confabulations: Evidence from a clinical case and combined MRI/DTI study",
abstract = "The Medio-Dorsal Nuclei (MDN) including the thalamic magnocellular and parvocellular thalamic regions has been implicated in verbal memory function. In a 77 year old lady, with a prior history of a clinically silent infarct of the left MDN, we observed the acute onset of spontaneous confabulations when an isolated new infarct occurred in the right MDN. The patient and five age-matched healthy subjects underwent Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI). The thalamic lesions were localized by overlapping Morel Thalamic Atlas with structural MRI data. DTI was used to assess: i) white matter alterations (Fractional Anisotropy, FA) within fibers connecting the ischemic areas to cortex; ii) the micro-structural damage (Mean Diffusivity) within the thalamic sub-regions defined by their structural connectivity to the Anterior Cingulate Cortex (ACC) and to the temporal lobes. These target regions were chosen because their damage is considered associated with the appearance of confabulations. Thalamic lesions were localized within the parvocellular regions of the right and left MDNs. The structural connectivity study showed that the fiber tracts, connecting the bilaterally damaged thalamic regions with the frontal cortex, corresponded to the anterior thalamic radiations (ATR). FA within these tracts was significantly lower in the patient as compared to controls. Mean diffusivity within the MDNs projecting to Broadman area (BA) 24, BA25 and BA32 of ACC was significantly higher in the patient than in control group. Mean diffusivity values within the MDN projecting to temporal lobes in contrast were not different between patient and controls. Our findings suggest the involvement of bilateral MDNs projections to ACC in the genesis of confabulations and help provide clarity to the longstanding debate on the origin of confabulations.",
keywords = "Amnesia, Confabulation, Medio-dorsal thalamic region",
author = "Valeria Onofrj and {Delli Pizzi}, Stefano and Raffaella Franciotti and Taylor, {John Paul} and Bernardo Perfetti and Massimo Caulo and Marco Onofrj and Laura Bonanni",
year = "2016",
doi = "10.1016/j.nicl.2016.10.011",
language = "English",
volume = "12",
pages = "776--784",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "ELSEVIER SCI LTD",

}

TY - JOUR

T1 - Medio-dorsal thalamus and confabulations

T2 - Evidence from a clinical case and combined MRI/DTI study

AU - Onofrj, Valeria

AU - Delli Pizzi, Stefano

AU - Franciotti, Raffaella

AU - Taylor, John Paul

AU - Perfetti, Bernardo

AU - Caulo, Massimo

AU - Onofrj, Marco

AU - Bonanni, Laura

PY - 2016

Y1 - 2016

N2 - The Medio-Dorsal Nuclei (MDN) including the thalamic magnocellular and parvocellular thalamic regions has been implicated in verbal memory function. In a 77 year old lady, with a prior history of a clinically silent infarct of the left MDN, we observed the acute onset of spontaneous confabulations when an isolated new infarct occurred in the right MDN. The patient and five age-matched healthy subjects underwent Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI). The thalamic lesions were localized by overlapping Morel Thalamic Atlas with structural MRI data. DTI was used to assess: i) white matter alterations (Fractional Anisotropy, FA) within fibers connecting the ischemic areas to cortex; ii) the micro-structural damage (Mean Diffusivity) within the thalamic sub-regions defined by their structural connectivity to the Anterior Cingulate Cortex (ACC) and to the temporal lobes. These target regions were chosen because their damage is considered associated with the appearance of confabulations. Thalamic lesions were localized within the parvocellular regions of the right and left MDNs. The structural connectivity study showed that the fiber tracts, connecting the bilaterally damaged thalamic regions with the frontal cortex, corresponded to the anterior thalamic radiations (ATR). FA within these tracts was significantly lower in the patient as compared to controls. Mean diffusivity within the MDNs projecting to Broadman area (BA) 24, BA25 and BA32 of ACC was significantly higher in the patient than in control group. Mean diffusivity values within the MDN projecting to temporal lobes in contrast were not different between patient and controls. Our findings suggest the involvement of bilateral MDNs projections to ACC in the genesis of confabulations and help provide clarity to the longstanding debate on the origin of confabulations.

AB - The Medio-Dorsal Nuclei (MDN) including the thalamic magnocellular and parvocellular thalamic regions has been implicated in verbal memory function. In a 77 year old lady, with a prior history of a clinically silent infarct of the left MDN, we observed the acute onset of spontaneous confabulations when an isolated new infarct occurred in the right MDN. The patient and five age-matched healthy subjects underwent Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI). The thalamic lesions were localized by overlapping Morel Thalamic Atlas with structural MRI data. DTI was used to assess: i) white matter alterations (Fractional Anisotropy, FA) within fibers connecting the ischemic areas to cortex; ii) the micro-structural damage (Mean Diffusivity) within the thalamic sub-regions defined by their structural connectivity to the Anterior Cingulate Cortex (ACC) and to the temporal lobes. These target regions were chosen because their damage is considered associated with the appearance of confabulations. Thalamic lesions were localized within the parvocellular regions of the right and left MDNs. The structural connectivity study showed that the fiber tracts, connecting the bilaterally damaged thalamic regions with the frontal cortex, corresponded to the anterior thalamic radiations (ATR). FA within these tracts was significantly lower in the patient as compared to controls. Mean diffusivity within the MDNs projecting to Broadman area (BA) 24, BA25 and BA32 of ACC was significantly higher in the patient than in control group. Mean diffusivity values within the MDN projecting to temporal lobes in contrast were not different between patient and controls. Our findings suggest the involvement of bilateral MDNs projections to ACC in the genesis of confabulations and help provide clarity to the longstanding debate on the origin of confabulations.

KW - Amnesia

KW - Confabulation

KW - Medio-dorsal thalamic region

UR - http://www.scopus.com/inward/record.url?scp=84992573763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992573763&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2016.10.011

DO - 10.1016/j.nicl.2016.10.011

M3 - Article

VL - 12

SP - 776

EP - 784

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -