Meditation training for people with amyotrophic lateral sclerosis: a randomized clinical trial

F Pagnini, A Marconi, A Tagliaferri, G M Manzoni, R Gatto, V Fabiani, G Gragnano, G Rossi, E Volpato, P Banfi, A Palmieri, F Graziano, G Castelnuovo, M Corbo, E Molinari, N Riva, V Sansone, C Lunetta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the use of an ALS-specific mindfulness-based intervention for improving quality of life in this population.

METHODS: A randomized, open-label and controlled clinical trial was conducted on the efficacy of an ALS-specific meditation programme in promoting quality of life. Adults who received a diagnosis of ALS within 18 months were randomly assigned either to usual care or to an 8-week meditation training based on the original mindfulness-based stress reduction programme and tailored for people with ALS. Quality of life, assessed with the ALS-Specific Quality of Life Revised scale, represented the primary outcome, whilst secondary outcomes included anxiety and depression, assessed with the Hospital Anxiety and Depression Scale, and specific quality of life domains. Participants were assessed at recruitment and after 2, 6 and 12 months. The efficacy of the treatment was assessed on an intention-to-treat basis of a linear mixed model.

RESULTS: A hundred participants were recruited between November 2012 and December 2014. Over time, there was a significant difference between the two groups in terms of quality of life (β = 0.24, P = 0.015, d = 0.89). Significant differences between groups over time were also found for anxiety, depression, negative emotions, and interaction with people and the environment.

CONCLUSIONS: An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.

Original languageEnglish
Pages (from-to)578-586
Number of pages9
JournalEuropean Journal of Neurology
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Meditation
Amyotrophic Lateral Sclerosis
Randomized Controlled Trials
Quality of Life
Mindfulness
Anxiety
Depression
Psychology
Controlled Clinical Trials
Linear Models
Emotions

Keywords

  • Aged
  • Amyotrophic Lateral Sclerosis
  • Anxiety
  • Depression
  • Female
  • Humans
  • Male
  • Meditation
  • Middle Aged
  • Quality of Life
  • Stress, Psychological
  • Treatment Outcome
  • Journal Article
  • Randomized Controlled Trial

Cite this

Meditation training for people with amyotrophic lateral sclerosis : a randomized clinical trial. / Pagnini, F; Marconi, A; Tagliaferri, A; Manzoni, G M; Gatto, R; Fabiani, V; Gragnano, G; Rossi, G; Volpato, E; Banfi, P; Palmieri, A; Graziano, F; Castelnuovo, G; Corbo, M; Molinari, E; Riva, N; Sansone, V; Lunetta, C.

In: European Journal of Neurology, Vol. 24, No. 4, 04.2017, p. 578-586.

Research output: Contribution to journalArticle

Pagnini, F, Marconi, A, Tagliaferri, A, Manzoni, GM, Gatto, R, Fabiani, V, Gragnano, G, Rossi, G, Volpato, E, Banfi, P, Palmieri, A, Graziano, F, Castelnuovo, G, Corbo, M, Molinari, E, Riva, N, Sansone, V & Lunetta, C 2017, 'Meditation training for people with amyotrophic lateral sclerosis: a randomized clinical trial', European Journal of Neurology, vol. 24, no. 4, pp. 578-586. https://doi.org/10.1111/ene.13246
Pagnini, F ; Marconi, A ; Tagliaferri, A ; Manzoni, G M ; Gatto, R ; Fabiani, V ; Gragnano, G ; Rossi, G ; Volpato, E ; Banfi, P ; Palmieri, A ; Graziano, F ; Castelnuovo, G ; Corbo, M ; Molinari, E ; Riva, N ; Sansone, V ; Lunetta, C. / Meditation training for people with amyotrophic lateral sclerosis : a randomized clinical trial. In: European Journal of Neurology. 2017 ; Vol. 24, No. 4. pp. 578-586.
@article{96355d5ee0b34d6dad480e0e587d9398,
title = "Meditation training for people with amyotrophic lateral sclerosis: a randomized clinical trial",
abstract = "BACKGROUND AND PURPOSE: Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the use of an ALS-specific mindfulness-based intervention for improving quality of life in this population.METHODS: A randomized, open-label and controlled clinical trial was conducted on the efficacy of an ALS-specific meditation programme in promoting quality of life. Adults who received a diagnosis of ALS within 18 months were randomly assigned either to usual care or to an 8-week meditation training based on the original mindfulness-based stress reduction programme and tailored for people with ALS. Quality of life, assessed with the ALS-Specific Quality of Life Revised scale, represented the primary outcome, whilst secondary outcomes included anxiety and depression, assessed with the Hospital Anxiety and Depression Scale, and specific quality of life domains. Participants were assessed at recruitment and after 2, 6 and 12 months. The efficacy of the treatment was assessed on an intention-to-treat basis of a linear mixed model.RESULTS: A hundred participants were recruited between November 2012 and December 2014. Over time, there was a significant difference between the two groups in terms of quality of life (β = 0.24, P = 0.015, d = 0.89). Significant differences between groups over time were also found for anxiety, depression, negative emotions, and interaction with people and the environment.CONCLUSIONS: An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.",
keywords = "Aged, Amyotrophic Lateral Sclerosis, Anxiety, Depression, Female, Humans, Male, Meditation, Middle Aged, Quality of Life, Stress, Psychological, Treatment Outcome, Journal Article, Randomized Controlled Trial",
author = "F Pagnini and A Marconi and A Tagliaferri and Manzoni, {G M} and R Gatto and V Fabiani and G Gragnano and G Rossi and E Volpato and P Banfi and A Palmieri and F Graziano and G Castelnuovo and M Corbo and E Molinari and N Riva and V Sansone and C Lunetta",
note = "{\circledC} 2017 EAN.",
year = "2017",
month = "4",
doi = "10.1111/ene.13246",
language = "English",
volume = "24",
pages = "578--586",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",

}

TY - JOUR

T1 - Meditation training for people with amyotrophic lateral sclerosis

T2 - a randomized clinical trial

AU - Pagnini, F

AU - Marconi, A

AU - Tagliaferri, A

AU - Manzoni, G M

AU - Gatto, R

AU - Fabiani, V

AU - Gragnano, G

AU - Rossi, G

AU - Volpato, E

AU - Banfi, P

AU - Palmieri, A

AU - Graziano, F

AU - Castelnuovo, G

AU - Corbo, M

AU - Molinari, E

AU - Riva, N

AU - Sansone, V

AU - Lunetta, C

N1 - © 2017 EAN.

PY - 2017/4

Y1 - 2017/4

N2 - BACKGROUND AND PURPOSE: Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the use of an ALS-specific mindfulness-based intervention for improving quality of life in this population.METHODS: A randomized, open-label and controlled clinical trial was conducted on the efficacy of an ALS-specific meditation programme in promoting quality of life. Adults who received a diagnosis of ALS within 18 months were randomly assigned either to usual care or to an 8-week meditation training based on the original mindfulness-based stress reduction programme and tailored for people with ALS. Quality of life, assessed with the ALS-Specific Quality of Life Revised scale, represented the primary outcome, whilst secondary outcomes included anxiety and depression, assessed with the Hospital Anxiety and Depression Scale, and specific quality of life domains. Participants were assessed at recruitment and after 2, 6 and 12 months. The efficacy of the treatment was assessed on an intention-to-treat basis of a linear mixed model.RESULTS: A hundred participants were recruited between November 2012 and December 2014. Over time, there was a significant difference between the two groups in terms of quality of life (β = 0.24, P = 0.015, d = 0.89). Significant differences between groups over time were also found for anxiety, depression, negative emotions, and interaction with people and the environment.CONCLUSIONS: An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.

AB - BACKGROUND AND PURPOSE: Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the use of an ALS-specific mindfulness-based intervention for improving quality of life in this population.METHODS: A randomized, open-label and controlled clinical trial was conducted on the efficacy of an ALS-specific meditation programme in promoting quality of life. Adults who received a diagnosis of ALS within 18 months were randomly assigned either to usual care or to an 8-week meditation training based on the original mindfulness-based stress reduction programme and tailored for people with ALS. Quality of life, assessed with the ALS-Specific Quality of Life Revised scale, represented the primary outcome, whilst secondary outcomes included anxiety and depression, assessed with the Hospital Anxiety and Depression Scale, and specific quality of life domains. Participants were assessed at recruitment and after 2, 6 and 12 months. The efficacy of the treatment was assessed on an intention-to-treat basis of a linear mixed model.RESULTS: A hundred participants were recruited between November 2012 and December 2014. Over time, there was a significant difference between the two groups in terms of quality of life (β = 0.24, P = 0.015, d = 0.89). Significant differences between groups over time were also found for anxiety, depression, negative emotions, and interaction with people and the environment.CONCLUSIONS: An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.

KW - Aged

KW - Amyotrophic Lateral Sclerosis

KW - Anxiety

KW - Depression

KW - Female

KW - Humans

KW - Male

KW - Meditation

KW - Middle Aged

KW - Quality of Life

KW - Stress, Psychological

KW - Treatment Outcome

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1111/ene.13246

DO - 10.1111/ene.13246

M3 - Article

C2 - 28229508

VL - 24

SP - 578

EP - 586

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 4

ER -