Mediterranean, but not lacto-ovo-vegetarian, diet positively influence circulating progenitor cells for cardiovascular prevention: The CARDIVEG study

F. Cesari, M. Dinu, G. Pagliai, A. Rogolino, B. Giusti, A. M. Gori, A. Casini, R. Marcucci, F. Sofi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the possible association between dietary habits and progenitor cells using data obtained from a randomized crossover trial using two different diets, lacto-ovo-vegetarian (VD) and Mediterranean (MD), the CARDIVEG study. Methods and results: Eighty clinically healthy subjects with a low-to-moderate cardiovascular risk profile (61 F; 19 M; mean age: 50.7 ± 11.6 years) were randomly assigned to isocaloric VD and MD diets lasting three months each, and then crossed. The two diets showed no effects on endothelial progenitor cells and circulating endothelial cells but opposite effects on circulating progenitor cells. In fact, VD determined significant (p < 0.05) and negative changes on circulating progenitor cells, with an average geometric variation of −130 cells/10 6 events for CD34 + /CD45 –/dim , −80 cells/10 6 events for CD133 + /CD45 –/dim , and −84 cells/10 6 events for CD34 + /CD133 + /CD45 –/dim while MD determined significant (p < 0.05) and positive changes for CD34 + /CD45 –/dim levels, with a geometric mean increase of +54 cells/10 6 events. No significant correlations were observed between changes in progenitor cells and changes in inflammatory parameters during the VD phase. On the other hand, during the MD phase negative correlations between changes of CD34 + /CD45 –/dim and interleukin-6 (R = −0.324; p = 0.004) as well as interleukin-8 (R = −0.228; p = 0.04) and monocyte chemotactic protein-1 (R = −0.277; p = 0.01), were observed. These correlations remained significant also after adjustment for confounding factors only for CD34 + /CD45 –/dim and interleukin-6 (β = −0.282; p = 0.018) and monocyte chemotactic protein-1 (β = −0.254; p = 0.031). Conclusions: MD, but not VD, reported a significant and positive effect on circulating progenitor cells in a group of subjects at low-to-moderate cardiovascular risk, probably acting through the modulation of inflammatory parameters.

Original languageEnglish
JournalNutrition, Metabolism and Cardiovascular Diseases
DOIs
Publication statusPublished - Jun 19 2019

Keywords

  • Mediterranean diet
  • Progenitor cells
  • Vegetarian diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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