Mediterranean Diet and Bladder Cancer Risk in Italy

Francesca Bravi, Maria-Eleni Spei, Jerry Polesel, Matteo Di Maso, Maurizio Montella, Monica Ferraroni, Diego Serraino, Massimo Libra, Eva Negri, Carlo La Vecchia, Federica Turati

Research output: Contribution to journalArticle

Abstract

Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54⁻0.98) for MDS of 4⁻5 and 0.66 (95% CI, 0.47⁻0.93) for MDS of 6⁻9 (p for trend = 0.02) compared to MDS = 0⁻3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1⁻pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer.

Original languageEnglish
JournalNutrients
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 10 2018

Fingerprint

Mediterranean Diet
Mediterranean diet
Urinary Bladder Neoplasms
Italy
odds ratio
urinary bladder neoplasms
Logistic Models
Odds Ratio
neoplasms
Sex Education
case-control studies
bladder
Fabaceae
Vegetables
carcinoma
Case-Control Studies
confidence interval
education
Neoplasms
Fishes

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Diet, Mediterranean
  • Fabaceae
  • Female
  • Healthy Diet
  • Humans
  • Italy/epidemiology
  • Male
  • Middle Aged
  • Nutritive Value
  • Prognosis
  • Protective Factors
  • Recommended Dietary Allowances
  • Risk Assessment
  • Risk Factors
  • Risk Reduction Behavior
  • Seafood
  • Urinary Bladder Neoplasms/diagnosis
  • Vegetables

Cite this

Bravi, F., Spei, M-E., Polesel, J., Di Maso, M., Montella, M., Ferraroni, M., ... Turati, F. (2018). Mediterranean Diet and Bladder Cancer Risk in Italy. Nutrients, 10(8). https://doi.org/10.3390/nu10081061

Mediterranean Diet and Bladder Cancer Risk in Italy. / Bravi, Francesca; Spei, Maria-Eleni; Polesel, Jerry; Di Maso, Matteo; Montella, Maurizio; Ferraroni, Monica; Serraino, Diego; Libra, Massimo; Negri, Eva; La Vecchia, Carlo; Turati, Federica.

In: Nutrients, Vol. 10, No. 8, 10.08.2018.

Research output: Contribution to journalArticle

Bravi, F, Spei, M-E, Polesel, J, Di Maso, M, Montella, M, Ferraroni, M, Serraino, D, Libra, M, Negri, E, La Vecchia, C & Turati, F 2018, 'Mediterranean Diet and Bladder Cancer Risk in Italy', Nutrients, vol. 10, no. 8. https://doi.org/10.3390/nu10081061
Bravi, Francesca ; Spei, Maria-Eleni ; Polesel, Jerry ; Di Maso, Matteo ; Montella, Maurizio ; Ferraroni, Monica ; Serraino, Diego ; Libra, Massimo ; Negri, Eva ; La Vecchia, Carlo ; Turati, Federica. / Mediterranean Diet and Bladder Cancer Risk in Italy. In: Nutrients. 2018 ; Vol. 10, No. 8.
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AU - Spei, Maria-Eleni

AU - Polesel, Jerry

AU - Di Maso, Matteo

AU - Montella, Maurizio

AU - Ferraroni, Monica

AU - Serraino, Diego

AU - Libra, Massimo

AU - Negri, Eva

AU - La Vecchia, Carlo

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N2 - Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54⁻0.98) for MDS of 4⁻5 and 0.66 (95% CI, 0.47⁻0.93) for MDS of 6⁻9 (p for trend = 0.02) compared to MDS = 0⁻3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1⁻pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer.

AB - Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54⁻0.98) for MDS of 4⁻5 and 0.66 (95% CI, 0.47⁻0.93) for MDS of 6⁻9 (p for trend = 0.02) compared to MDS = 0⁻3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1⁻pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer.

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KW - Vegetables

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