Mediterranean Diet and Breast Cancer Risk

Federica Turati, Greta Carioli, Francesca Bravi, Monica Ferraroni, Diego Serraino, Maurizio Montella, Attilio Giacosa, Federica Toffolutti, Eva Negri, Fabio Levi, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

The Mediterranean diet has been related to a reduced risk of several common cancers but its role on breast cancer has not been quantified yet. We investigated the association between adherence to the Mediterranean diet and breast cancer risk by means of a hospital-based case-control study conducted in Italy and Switzerland. 3034 breast cancer cases and 3392 controls admitted to the same network of hospitals for acute, non-neoplastic and non-gynaecologic diseases were studied. Adherence to the Mediterranean diet was quantitatively measured through a Mediterranean Diet Score (MDS), summarizing the major characteristics of the Mediterranean dietary pattern and ranging from 0 (lowest adherence) to 9 (highest adherence). We estimated the odds ratios (ORs) of breast cancer for the MDS using multiple logistic regression models, adjusting for several covariates. Compared to a MDS of 0-3, the ORs for breast cancer were 0.86 (95% confidence interval, CI, 0.76-0.98) for a MDS of 4-5 and 0.82 (95% CI, 0.71-0.95) for a MDS of 6-9 (p for trend = 0.008). The exclusion of the ethanol component from the MDS did not materially modify the ORs (e.g., OR = 0.81, 95% CI, 0.70-0.95, for MDS ≥ 6). Results were similar in pre- and post-menopausal women. Adherence to the Mediterranean diet was associated with a reduced breast cancer risk.

Original languageEnglish
JournalNutrients
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 8 2018

Fingerprint

Mediterranean Diet
Mediterranean diet
breast neoplasms
Breast Neoplasms
odds ratio
Odds Ratio
menopause
Logistic Models
case-control studies
Switzerland
eating habits
Italy
Case-Control Studies
confidence interval
Ethanol

Keywords

  • Adult
  • Aged
  • Breast Neoplasms/epidemiology
  • Case-Control Studies
  • Diet, Mediterranean
  • Female
  • Humans
  • Italy/epidemiology
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Risk Reduction Behavior
  • Switzerland/epidemiology

Cite this

Turati, F., Carioli, G., Bravi, F., Ferraroni, M., Serraino, D., Montella, M., ... La Vecchia, C. (2018). Mediterranean Diet and Breast Cancer Risk. Nutrients, 10(3). https://doi.org/10.3390/nu10030326

Mediterranean Diet and Breast Cancer Risk. / Turati, Federica; Carioli, Greta; Bravi, Francesca; Ferraroni, Monica; Serraino, Diego; Montella, Maurizio; Giacosa, Attilio; Toffolutti, Federica; Negri, Eva; Levi, Fabio; La Vecchia, Carlo.

In: Nutrients, Vol. 10, No. 3, 08.03.2018.

Research output: Contribution to journalArticle

Turati, F, Carioli, G, Bravi, F, Ferraroni, M, Serraino, D, Montella, M, Giacosa, A, Toffolutti, F, Negri, E, Levi, F & La Vecchia, C 2018, 'Mediterranean Diet and Breast Cancer Risk', Nutrients, vol. 10, no. 3. https://doi.org/10.3390/nu10030326
Turati, Federica ; Carioli, Greta ; Bravi, Francesca ; Ferraroni, Monica ; Serraino, Diego ; Montella, Maurizio ; Giacosa, Attilio ; Toffolutti, Federica ; Negri, Eva ; Levi, Fabio ; La Vecchia, Carlo. / Mediterranean Diet and Breast Cancer Risk. In: Nutrients. 2018 ; Vol. 10, No. 3.
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