Abstract
Background:Adherence to the Mediterranean diet (MD) is associated with a reduced risk of several cancers. However, studies conducted in Mediterranean regions are scanty.Methods:To investigate the relation between MD and colorectal cancer risk in Italy, we pooled data from three case–control studies, including a total of 3745 colorectal cancer cases and 6804 hospital controls. Adherence to the MD was assessed using an a priori Mediterranean Diet Score (MDS), based on nine components.Results:Compared with the lowest adherence to the MD (0–2 MDS), the odds ratio (OR) was 0.52 (95% confidence interval (CI) 0.43–0.62) for the highest adherence (7–9 MDS), with a significant inverse trend in risk (P<0.0001). The OR for a 1-point increment in the MDS was 0.89 (95% CI 0.86–0.91). The inverse association was consistent across studies, cancer anatomical subsites and strata of selected covariates.Conclusions:This Italian study confirms a favourable role of MD on colorectal cancer risk.British Journal of Cancer advance online publication, 18 August 2016; doi:10.1038/bjc.2016.245 www.bjcancer.com.
| Original language | English |
|---|---|
| Journal | British Journal of Cancer |
| DOIs | |
| Publication status | Accepted/In press - Aug 18 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Oncology
- Cancer Research
Cite this
Mediterranean diet and colorectal cancer risk : a pooled analysis of three Italian case–control studies. / Rosato, Valentina; Guercio, Valentina; Bosetti, Cristina; Negri, Eva Vanna Lorenza; Serraino, Diego; Giacosa, Attilio; Montella, Maurizio; La Vecchia, Carlo; Tavani, Alessandra.
In: British Journal of Cancer, 18.08.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mediterranean diet and colorectal cancer risk
T2 - a pooled analysis of three Italian case–control studies
AU - Rosato, Valentina
AU - Guercio, Valentina
AU - Bosetti, Cristina
AU - Negri, Eva Vanna Lorenza
AU - Serraino, Diego
AU - Giacosa, Attilio
AU - Montella, Maurizio
AU - La Vecchia, Carlo
AU - Tavani, Alessandra
PY - 2016/8/18
Y1 - 2016/8/18
N2 - Background:Adherence to the Mediterranean diet (MD) is associated with a reduced risk of several cancers. However, studies conducted in Mediterranean regions are scanty.Methods:To investigate the relation between MD and colorectal cancer risk in Italy, we pooled data from three case–control studies, including a total of 3745 colorectal cancer cases and 6804 hospital controls. Adherence to the MD was assessed using an a priori Mediterranean Diet Score (MDS), based on nine components.Results:Compared with the lowest adherence to the MD (0–2 MDS), the odds ratio (OR) was 0.52 (95% confidence interval (CI) 0.43–0.62) for the highest adherence (7–9 MDS), with a significant inverse trend in risk (P<0.0001). The OR for a 1-point increment in the MDS was 0.89 (95% CI 0.86–0.91). The inverse association was consistent across studies, cancer anatomical subsites and strata of selected covariates.Conclusions:This Italian study confirms a favourable role of MD on colorectal cancer risk.British Journal of Cancer advance online publication, 18 August 2016; doi:10.1038/bjc.2016.245 www.bjcancer.com.
AB - Background:Adherence to the Mediterranean diet (MD) is associated with a reduced risk of several cancers. However, studies conducted in Mediterranean regions are scanty.Methods:To investigate the relation between MD and colorectal cancer risk in Italy, we pooled data from three case–control studies, including a total of 3745 colorectal cancer cases and 6804 hospital controls. Adherence to the MD was assessed using an a priori Mediterranean Diet Score (MDS), based on nine components.Results:Compared with the lowest adherence to the MD (0–2 MDS), the odds ratio (OR) was 0.52 (95% confidence interval (CI) 0.43–0.62) for the highest adherence (7–9 MDS), with a significant inverse trend in risk (P<0.0001). The OR for a 1-point increment in the MDS was 0.89 (95% CI 0.86–0.91). The inverse association was consistent across studies, cancer anatomical subsites and strata of selected covariates.Conclusions:This Italian study confirms a favourable role of MD on colorectal cancer risk.British Journal of Cancer advance online publication, 18 August 2016; doi:10.1038/bjc.2016.245 www.bjcancer.com.
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U2 - 10.1038/bjc.2016.245
DO - 10.1038/bjc.2016.245
M3 - Article
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
ER -