Mediterranean diet and hepatocellular carcinoma

Federica Turati, Dimitrios Trichopoulos, Jerry Polesel, Francesca Bravi, Marta Rossi, Renato Talamini, Silvia Franceschi, Maurizio Montella, Antonia Trichopoulou, Carlo La Vecchia, Pagona Lagiou

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Background & Aims Hepatocellular carcinoma (HCC) has a very poor prognosis and any effort to identify additional risk factors, besides those already established, would be important for the prevention of the disease. Data on the role of diet on HCC risk are still controversial. Methods We have evaluated the association of adherence to the Mediterranean diet with HCC risk, as well as the interaction of this dietary pattern with chronic hepatitis infection, by combining two case-control studies undertaken in Italy and Greece, including overall 518 cases of HCC and 772 controls. Adherence to the traditional Mediterranean diet was assessed through the Mediterranean diet score (MDS), which ranges between 0 (lowest adherence) and 9 (highest adherence). Odds ratios (OR) for HCC were obtained through multiple logistic regression models, controlling for potentially confounding factors, including chronic infection with hepatitis B/C viruses. Results Compared to MDS of 0-3, the ORs for HCC were 0.66 (95% confidence interval (CI), 0.41-1.04) for MDS equal to 4 and 0.51 (95% CI, 0.34-0.75) for MDS ≥5, with a significant trend (p

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalJournal of Hepatology
Issue number3
Publication statusPublished - Mar 2014



  • Case-control study
  • Dietary habits
  • Liver cancer
  • Mediterranean diet
  • Risk factors

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

Cite this

Turati, F., Trichopoulos, D., Polesel, J., Bravi, F., Rossi, M., Talamini, R., Franceschi, S., Montella, M., Trichopoulou, A., La Vecchia, C., & Lagiou, P. (2014). Mediterranean diet and hepatocellular carcinoma. Journal of Hepatology, 60(3), 606-611.