Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality: A cohort study in an Italian population

Federica Prinelli, Mary Yannakoulia, Costas A. Anastasiou, Fulvio Adorni, Simona G. Di Santo, Massimo Musicco, Nikolaos Scarmeas, Maria L. Correa Leite

Research output: Contribution to journalArticle

Abstract

The aim of the present analysis was to evaluate the association of the Mediterranean diet (MeDi), smoking habits and physical activity with all-cause mortality in an Italian population during a 20-year follow-up study. A total of 1693 subjects aged 40-74 who enrolled in the study in 1991-5 were asked about dietary and other lifestyle information at baseline. Adherence to the MeDi was evaluated by the Mediterranean dietary score (MedDietScore). A healthy lifestyle score was computed by assigning 1 point each for a medium or high adherence to the MedDietScore, non-smoking and physical activity. Cox models were used to assess the associations between lifestyle factors and healthy lifestyle scores and all-cause mortality, adjusting for potential confounders. The final sample included 974 subjects with complete data and without chronic disease at baseline. During a median of 17·4 years of follow-up, 193 people died. Subjects with high adherence to the MedDietScore (hazard ratio (HR) 0·62, 95 % CI 0·43, 0·89)), non-smokers (HR 0·71, 95 % CI 0·51, 0·98) and physically active subjects (HR 0·55, 95 % CI 0·36, 0·82) were at low risk of death. Each point increase in the MedDietScore was associated with a significant 5 % reduction of death risk. Subjects with 1, 2 or 3 healthy lifestyle behaviours had a significantly 39, 56, and 73 % reduced risk of death, respectively. A high adherence to MeDi, non-smoking and physical activity were strongly associated with a reduced risk of all-cause mortality in healthy subjects after long-term follow-up. This reduction was even stronger when the healthy lifestyle behaviours were combined.

Original languageEnglish
Pages (from-to)1003-1011
Number of pages9
JournalBritish Journal of Nutrition
Volume113
Issue number6
DOIs
Publication statusPublished - Mar 28 2015

Fingerprint

Mediterranean Diet
Life Style
Cohort Studies
Mortality
Population
Exercise
Feeding Behavior
Risk Reduction Behavior
Proportional Hazards Models
Healthy Volunteers
Chronic Disease
Smoking
Healthy Lifestyle

Keywords

  • All-cause mortality
  • Follow-up studies
  • Lifestyle factors
  • Mediterranean diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Prinelli, F., Yannakoulia, M., Anastasiou, C. A., Adorni, F., Di Santo, S. G., Musicco, M., ... Correa Leite, M. L. (2015). Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality: A cohort study in an Italian population. British Journal of Nutrition, 113(6), 1003-1011. https://doi.org/10.1017/S0007114515000318

Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality : A cohort study in an Italian population. / Prinelli, Federica; Yannakoulia, Mary; Anastasiou, Costas A.; Adorni, Fulvio; Di Santo, Simona G.; Musicco, Massimo; Scarmeas, Nikolaos; Correa Leite, Maria L.

In: British Journal of Nutrition, Vol. 113, No. 6, 28.03.2015, p. 1003-1011.

Research output: Contribution to journalArticle

Prinelli, F, Yannakoulia, M, Anastasiou, CA, Adorni, F, Di Santo, SG, Musicco, M, Scarmeas, N & Correa Leite, ML 2015, 'Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality: A cohort study in an Italian population', British Journal of Nutrition, vol. 113, no. 6, pp. 1003-1011. https://doi.org/10.1017/S0007114515000318
Prinelli, Federica ; Yannakoulia, Mary ; Anastasiou, Costas A. ; Adorni, Fulvio ; Di Santo, Simona G. ; Musicco, Massimo ; Scarmeas, Nikolaos ; Correa Leite, Maria L. / Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality : A cohort study in an Italian population. In: British Journal of Nutrition. 2015 ; Vol. 113, No. 6. pp. 1003-1011.
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