TY - JOUR
T1 - Mediterranean diet and quality of life in women treated for breast cancer
T2 - A baseline analysis of DEDiCa multicentre trial
AU - Porciello, Giuseppe
AU - Montagnese, Concetta
AU - Crispo, Anna
AU - Grimaldi, Maria
AU - Libra, Massimo
AU - Vitale, Sara
AU - Palumbo, Elvira
AU - Pica, Rosa
AU - Calabrese, Ilaria
AU - Cubisino, Serena
AU - Falzone, Luca
AU - Poletto, Luigina
AU - Martinuzzo, Valentina
AU - Prete, Melania
AU - Esindi, Nadia
AU - Thomas, Guglielmo
AU - Cianniello, Daniela
AU - Pinto, Monica
AU - de Laurentiis, Michelino
AU - Pacilio, Carmen
AU - Rinaldo, Massimo
AU - D’Aiuto, Massimiliano
AU - Serraino, Diego
AU - Massarut, Samuele
AU - Evangelista, Chiara
AU - Steffan, Agostino
AU - Catalano, Francesca
AU - Banna, Giuseppe L.
AU - Scandurra, Giuseppa
AU - Ferraù, Francesco
AU - Rossello, Rosalba
AU - Antonelli, Giovanna
AU - Guerra, Gennaro
AU - Farina, Amalia
AU - Messina, Francesco
AU - Riccardi, Gabriele
AU - Gatti, Davide
AU - Jenkins, David J.A.
AU - Minopoli, Anita
AU - Grilli, Bruna
AU - Cavalcanti, Ernesta
AU - Celentano, Egidio
AU - Botti, Gerardo
AU - Montella, Maurizio
AU - Augustin, Livia S.A.
N1 - Publisher Copyright:
Copyright: © 2020 Porciello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used to analyse adherence to the MedDiet. HRQoL was assessed with three validated questionnaires measuring physical, mental, emotional and social factors: EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Analysis of variance (ANOVA) and multivariate analyses were performed to assess the possible role of the MedDiet on HRQoL. Patients with higher adherence to MedDiet (PREDIMED score >7) showed significantly higher scores for physical functioning (p = 0.02) and lower scores on the symptomatic pain scale (p = 0.04) assessed by the EORTC QLQ-C30 questionnaire compared to patients with a lower adherence to MedDiet (PREDIMED score ≤7). Higher scores from the EQ-5D-3L indicating higher well-being were observed mainly in participants with higher MedDiet adherence (p = 0.05). In adjusted multivariate analyses significant positive associations were found between MedDiet, physical functioning (p = 0.001) and EQ 5D-3L score (p = 0.003) while inverse associations were found with pain and insomnia symptoms (p = 0.005 and p = 0.029, respectively). These results suggest that higher adherence to the MedDiet in breast cancer survivors is associated with better aspects of quality of life, specifically higher physical functioning, better sleep, lower pain and generally higher well-being confirming findings in healthy subjects.
AB - Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used to analyse adherence to the MedDiet. HRQoL was assessed with three validated questionnaires measuring physical, mental, emotional and social factors: EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Analysis of variance (ANOVA) and multivariate analyses were performed to assess the possible role of the MedDiet on HRQoL. Patients with higher adherence to MedDiet (PREDIMED score >7) showed significantly higher scores for physical functioning (p = 0.02) and lower scores on the symptomatic pain scale (p = 0.04) assessed by the EORTC QLQ-C30 questionnaire compared to patients with a lower adherence to MedDiet (PREDIMED score ≤7). Higher scores from the EQ-5D-3L indicating higher well-being were observed mainly in participants with higher MedDiet adherence (p = 0.05). In adjusted multivariate analyses significant positive associations were found between MedDiet, physical functioning (p = 0.001) and EQ 5D-3L score (p = 0.003) while inverse associations were found with pain and insomnia symptoms (p = 0.005 and p = 0.029, respectively). These results suggest that higher adherence to the MedDiet in breast cancer survivors is associated with better aspects of quality of life, specifically higher physical functioning, better sleep, lower pain and generally higher well-being confirming findings in healthy subjects.
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U2 - 10.1371/journal.pone.0239803
DO - 10.1371/journal.pone.0239803
M3 - Article
C2 - 33031478
AN - SCOPUS:85092650011
VL - 15
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10 October
M1 - e0239803
ER -