Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.

Maria Esther Molina-Montes; Maria-Jose Sanchez; Genevieve Buckland; H B as Bueno-de-Mesquita; Elisabete Weiderpass; Pilar Amiano; Petra A. Wark; Tilman Kuhn; Verena A. Katzke; Jose Maria Huerta; Eva Ardanaz; Jose Ramon Quiros; Aurelie Affret; Mathilde His; Marie Christine Boutron-Ruault; Petra P H Peeters; Weimin Ye; Malin Sund; Heiner Boeing; Khalid Iqbal; Bodil Ohlsson; Emily Sonestedt; Anne Tjonneland; Kristina En Petersen; Ruth C. Travis; Guri Skeie; Claudia Agnoli; Salvatore Panico; Domenico Palli; Rosario Tumino; Carlotta Sacerdote; Heinz Freisling; Inge Huybrechts; Kim Overvad; Antonia Trichopoulou; Christina Bamia; Effie Vasilopoulou; Nick Wareham; Kay Tee Khaw; Amanda J. Cross; Heather A. Ward; Elio Riboli; Eric J. Duell

doi:10.1038/bjc.2017.14

Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.

Maria Esther Molina-Montes, Maria-Jose Sanchez, Genevieve Buckland, H B as Bueno-de-Mesquita, Elisabete Weiderpass, Pilar Amiano, Petra A. Wark, Tilman Kuhn, Verena A. Katzke, Jose Maria Huerta, Eva Ardanaz, Jose Ramon Quiros, Aurelie Affret, Mathilde His, Marie Christine Boutron-Ruault, Petra P H Peeters, Weimin Ye, Malin Sund, Heiner Boeing, Khalid IqbalBodil Ohlsson, Emily Sonestedt, Anne Tjonneland, Kristina En Petersen, Ruth C. Travis, Guri Skeie, Claudia Agnoli, Salvatore Panico, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Heinz Freisling, Inge Huybrechts, Kim Overvad, Antonia Trichopoulou, Christina Bamia, Effie Vasilopoulou, Nick Wareham, Kay Tee Khaw, Amanda J. Cross, Heather A. Ward, Elio Riboli, Eric J. Duell

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

BACKGROUND: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). RESULTS: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. CONCLUSIONS: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

Original language	Undefined/Unknown
Pages (from-to)	811-820
Number of pages	10
Journal	British Journal of Cancer
Volume	116
Issue number	6
DOIs	https://doi.org/10.1038/bjc.2017.14
Publication status	Published - Mar 1 2017

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10.1038/bjc.2017.14

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Molina-Montes, M. E., Sanchez, M-J., Buckland, G., Bueno-de-Mesquita, H. B. A., Weiderpass, E., Amiano, P., Wark, P. A., Kuhn, T., Katzke, V. A., Huerta, J. M., Ardanaz, E., Quiros, J. R., Affret, A., His, M., Boutron-Ruault, M. C., Peeters, P. P. H., Ye, W., Sund, M., Boeing, H., ... Duell, E. J. (2017). Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer, 116(6), 811-820. https://doi.org/10.1038/bjc.2017.14

Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. / Molina-Montes, Maria Esther; Sanchez, Maria-Jose; Buckland, Genevieve; Bueno-de-Mesquita, H B as; Weiderpass, Elisabete; Amiano, Pilar; Wark, Petra A.; Kuhn, Tilman; Katzke, Verena A.; Huerta, Jose Maria; Ardanaz, Eva; Quiros, Jose Ramon; Affret, Aurelie; His, Mathilde; Boutron-Ruault, Marie Christine; Peeters, Petra P H; Ye, Weimin; Sund, Malin; Boeing, Heiner; Iqbal, Khalid; Ohlsson, Bodil; Sonestedt, Emily; Tjonneland, Anne; Petersen, Kristina En; Travis, Ruth C.; Skeie, Guri; Agnoli, Claudia; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; Freisling, Heinz; Huybrechts, Inge; Overvad, Kim; Trichopoulou, Antonia; Bamia, Christina; Vasilopoulou, Effie; Wareham, Nick; Khaw, Kay Tee; Cross, Amanda J.; Ward, Heather A.; Riboli, Elio; Duell, Eric J.

In: British Journal of Cancer, Vol. 116, No. 6, 01.03.2017, p. 811-820.

Research output: Contribution to journal › Article

Molina-Montes, ME, Sanchez, M-J, Buckland, G, Bueno-de-Mesquita, HBA, Weiderpass, E, Amiano, P, Wark, PA, Kuhn, T, Katzke, VA, Huerta, JM, Ardanaz, E, Quiros, JR, Affret, A, His, M, Boutron-Ruault, MC, Peeters, PPH, Ye, W, Sund, M, Boeing, H, Iqbal, K, Ohlsson, B, Sonestedt, E, Tjonneland, A, Petersen, KE, Travis, RC, Skeie, G, Agnoli, C, Panico, S, Palli, D, Tumino, R, Sacerdote, C, Freisling, H, Huybrechts, I, Overvad, K, Trichopoulou, A, Bamia, C, Vasilopoulou, E, Wareham, N, Khaw, KT, Cross, AJ, Ward, HA, Riboli, E & Duell, EJ 2017, 'Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.', British Journal of Cancer, vol. 116, no. 6, pp. 811-820. https://doi.org/10.1038/bjc.2017.14

Molina-Montes, Maria Esther ; Sanchez, Maria-Jose ; Buckland, Genevieve ; Bueno-de-Mesquita, H B as ; Weiderpass, Elisabete ; Amiano, Pilar ; Wark, Petra A. ; Kuhn, Tilman ; Katzke, Verena A. ; Huerta, Jose Maria ; Ardanaz, Eva ; Quiros, Jose Ramon ; Affret, Aurelie ; His, Mathilde ; Boutron-Ruault, Marie Christine ; Peeters, Petra P H ; Ye, Weimin ; Sund, Malin ; Boeing, Heiner ; Iqbal, Khalid ; Ohlsson, Bodil ; Sonestedt, Emily ; Tjonneland, Anne ; Petersen, Kristina En ; Travis, Ruth C. ; Skeie, Guri ; Agnoli, Claudia ; Panico, Salvatore ; Palli, Domenico ; Tumino, Rosario ; Sacerdote, Carlotta ; Freisling, Heinz ; Huybrechts, Inge ; Overvad, Kim ; Trichopoulou, Antonia ; Bamia, Christina ; Vasilopoulou, Effie ; Wareham, Nick ; Khaw, Kay Tee ; Cross, Amanda J. ; Ward, Heather A. ; Riboli, Elio ; Duell, Eric J. / Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. In: British Journal of Cancer. 2017 ; Vol. 116, No. 6. pp. 811-820.

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title = "Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.",

abstract = "BACKGROUND: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). RESULTS: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. CONCLUSIONS: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.",

author = "Molina-Montes, {Maria Esther} and Maria-Jose Sanchez and Genevieve Buckland and Bueno-de-Mesquita, {H B as} and Elisabete Weiderpass and Pilar Amiano and Wark, {Petra A.} and Tilman Kuhn and Katzke, {Verena A.} and Huerta, {Jose Maria} and Eva Ardanaz and Quiros, {Jose Ramon} and Aurelie Affret and Mathilde His and Boutron-Ruault, {Marie Christine} and Peeters, {Petra P H} and Weimin Ye and Malin Sund and Heiner Boeing and Khalid Iqbal and Bodil Ohlsson and Emily Sonestedt and Anne Tjonneland and Petersen, {Kristina En} and Travis, {Ruth C.} and Guri Skeie and Claudia Agnoli and Salvatore Panico and Domenico Palli and Rosario Tumino and Carlotta Sacerdote and Heinz Freisling and Inge Huybrechts and Kim Overvad and Antonia Trichopoulou and Christina Bamia and Effie Vasilopoulou and Nick Wareham and Khaw, {Kay Tee} and Cross, {Amanda J.} and Ward, {Heather A.} and Elio Riboli and Duell, {Eric J.}",

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T1 - Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.

AU - Molina-Montes, Maria Esther

AU - Sanchez, Maria-Jose

AU - Buckland, Genevieve

AU - Bueno-de-Mesquita, H B as

AU - Weiderpass, Elisabete

AU - Amiano, Pilar

AU - Wark, Petra A.

AU - Kuhn, Tilman

AU - Katzke, Verena A.

AU - Huerta, Jose Maria

AU - Ardanaz, Eva

AU - Quiros, Jose Ramon

AU - Affret, Aurelie

AU - His, Mathilde

AU - Boutron-Ruault, Marie Christine

AU - Peeters, Petra P H

AU - Ye, Weimin

AU - Sund, Malin

AU - Boeing, Heiner

AU - Iqbal, Khalid

AU - Ohlsson, Bodil

AU - Sonestedt, Emily

AU - Tjonneland, Anne

AU - Petersen, Kristina En

AU - Travis, Ruth C.

AU - Skeie, Guri

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Freisling, Heinz

AU - Huybrechts, Inge

AU - Overvad, Kim

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Vasilopoulou, Effie

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Cross, Amanda J.

AU - Ward, Heather A.

AU - Riboli, Elio

AU - Duell, Eric J.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). RESULTS: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. CONCLUSIONS: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

AB - BACKGROUND: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). RESULTS: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. CONCLUSIONS: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

U2 - 10.1038/bjc.2017.14

DO - 10.1038/bjc.2017.14

M3 - Articolo

VL - 116

SP - 811

EP - 820

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 6

ER -