Mediterranean diet in predementia and dementia syndromes

V. Solfrizzi, V. Frisardi, D. Seripa, G. Logroscino, B. P. Imbimbo, G. D'Onofrio, F. Addante, D. Sancarlo, L. Cascavilla, A. Pilotto, F. Panza

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

There is a critical need to potentially individualize new strategies able to prevent and to slow down the progression of predementia and dementia syndromes. Only recently higher adherence to a Mediterranean-type diet was associated with decreased cognitive decline although the Mediterranean diet (MeDi) combines several foods, micro- and macronutri-ents already separately proposed as potential protective factors against dementia and predementia syndromes. In fact, elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment (MCI). Furthermore, at present, epidemiological evidence suggested a possible association among fish consumption, monounsaturated fatty acids and polyunsaturated fatty acids (PUFA) (particularly, n-3 PUFA) and reduced risk of cognitive decline and dementia. Light to moderate alcohol use may be associated with a reduced risk of incident dementia and Alzheimer's disease (AD), while for vascular dementia, cognitive decline, and predementia syndromes the current evidence is only suggestive of a protective effect. Finally, the limited epidemiological evidence available on fruit and vegetable consumption and cognition generally supported a protective role of these macronutrients against cognitive decline, dementia, and AD. Moreover, recent prospective studies provided evidence that higher adherence to a Mediterranean-type diet could be associated with slower cognitive decline, reduced risk of progression from MCI to AD, reduced risk of AD, and decreased all-causes mortality in AD patients. These findings suggested that adherence to the MeDi may affect not only the risk for AD, but also for predementia syndromes and their progression to overt dementia. Nonetheless, at present, no definitive dietary recommendations are possible. However, high levels of consumption of fats from fish, vegetable oils, non-starchy vegetables, low glycemic fruits, and diet low in foods with added sugars and with moderate wine intake should be encouraged. In fact, this dietary advice is in accordance with recommendations for lowering the risk of cardiovascular disease, obesity, diabetes, and hypertension and might open new ways for the prevention and management of cognitive decline and dementia.

Original languageEnglish
Pages (from-to)520-542
Number of pages23
JournalCurrent Alzheimer Research
Volume8
Issue number5
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Mediterranean Diet
Dementia
Alzheimer Disease
Vegetables
Fruit
Cognitive Dysfunction
Food
Monounsaturated Fatty Acids
Vascular Dementia
Plant Oils
Fish Oils
Omega-3 Fatty Acids
Wine
Unsaturated Fatty Acids
Cognition
Fishes
Cardiovascular Diseases
Fatty Acids
Obesity
Fats

Keywords

  • Age-related cognitive decline
  • Alcohol consumption
  • Alzheimer's disease
  • Dementia
  • Fruits
  • Mediterranean diet adherence
  • Mild cognitive impairment
  • MUFA
  • Predementia syndromes
  • PUFA
  • Vascular dementia
  • Vegetables

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Solfrizzi, V., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., D'Onofrio, G., ... Panza, F. (2011). Mediterranean diet in predementia and dementia syndromes. Current Alzheimer Research, 8(5), 520-542. https://doi.org/10.2174/156720511796391809

Mediterranean diet in predementia and dementia syndromes. / Solfrizzi, V.; Frisardi, V.; Seripa, D.; Logroscino, G.; Imbimbo, B. P.; D'Onofrio, G.; Addante, F.; Sancarlo, D.; Cascavilla, L.; Pilotto, A.; Panza, F.

In: Current Alzheimer Research, Vol. 8, No. 5, 08.2011, p. 520-542.

Research output: Contribution to journalArticle

Solfrizzi, V, Frisardi, V, Seripa, D, Logroscino, G, Imbimbo, BP, D'Onofrio, G, Addante, F, Sancarlo, D, Cascavilla, L, Pilotto, A & Panza, F 2011, 'Mediterranean diet in predementia and dementia syndromes', Current Alzheimer Research, vol. 8, no. 5, pp. 520-542. https://doi.org/10.2174/156720511796391809
Solfrizzi, V. ; Frisardi, V. ; Seripa, D. ; Logroscino, G. ; Imbimbo, B. P. ; D'Onofrio, G. ; Addante, F. ; Sancarlo, D. ; Cascavilla, L. ; Pilotto, A. ; Panza, F. / Mediterranean diet in predementia and dementia syndromes. In: Current Alzheimer Research. 2011 ; Vol. 8, No. 5. pp. 520-542.
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