Medium adsorbance fraction of reticulocyte and myeloperoxidase index may individuate a patient subset with a low risk of chemotherapy-related neutropenia

Giulio Giordano, Pier Francisco Ferrucci, Chiara Nicci, Tiziana Grafone, Rosa Tambaro, Stefano Papini, Giuliana Farina, Silvia Piano, Bruno Zappacosta, Sergio Storti

Research output: Contribution to journalArticle

Abstract

In neoplastic patients chemotherapy frequently involves severe myeloid suppression. Sometimes myeloid suppression is the main cause of therapy recycling delay with severe and prolonged neutropenia, anaemia and thrombocytopenia. Our study aimed to verify whether there is a correlation between reticulocyte fractions, reticulocyte indices, myeloperoxidase index (MPXI) and post-chemotherapy myelopoietic function and severe post-chemotherapy neutropenia. A cohort of 112 patients was identified, 30 with lymphoma or myeloma and 82 with solid neoplasms with bone marrow micrometastases. The patients were treated with chemotherapy (CT). After CT, 60 patients had neutropenia (ANC 10.7% a score of 1, and a score of 0 was assigned to the remaining patients. Patients with a score of 1 showed a lower number of neutropenic events (only 9 out of 36 patients) than those with a score of 0 (51 out of 76 patients), p

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalOncology Reports
Volume21
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Chemotherapy
  • Medium absorbance fraction of reticulocyte
  • Myeloperoxidase index
  • Neutropenia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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