Abstract
In neoplastic patients chemotherapy frequently involves severe myeloid suppression. Sometimes myeloid suppression is the main cause of therapy recycling delay with severe and prolonged neutropenia, anaemia and thrombocytopenia. Our study aimed to verify whether there is a correlation between reticulocyte fractions, reticulocyte indices, myeloperoxidase index (MPXI) and post-chemotherapy myelopoietic function and severe post-chemotherapy neutropenia. A cohort of 112 patients was identified, 30 with lymphoma or myeloma and 82 with solid neoplasms with bone marrow micrometastases. The patients were treated with chemotherapy (CT). After CT, 60 patients had neutropenia (ANC 10.7% a score of 1, and a score of 0 was assigned to the remaining patients. Patients with a score of 1 showed a lower number of neutropenic events (only 9 out of 36 patients) than those with a score of 0 (51 out of 76 patients), p
| Original language | English |
|---|---|
| Pages (from-to) | 193-198 |
| Number of pages | 6 |
| Journal | Oncology Reports |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Chemotherapy
- Medium absorbance fraction of reticulocyte
- Myeloperoxidase index
- Neutropenia
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Medium adsorbance fraction of reticulocyte and myeloperoxidase index may individuate a patient subset with a low risk of chemotherapy-related neutropenia. / Giordano, Giulio; Ferrucci, Pier Francisco; Nicci, Chiara; Grafone, Tiziana; Tambaro, Rosa; Papini, Stefano; Farina, Giuliana; Piano, Silvia; Zappacosta, Bruno; Storti, Sergio.
In: Oncology Reports, Vol. 21, No. 1, 2009, p. 193-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Medium adsorbance fraction of reticulocyte and myeloperoxidase index may individuate a patient subset with a low risk of chemotherapy-related neutropenia
AU - Giordano, Giulio
AU - Ferrucci, Pier Francisco
AU - Nicci, Chiara
AU - Grafone, Tiziana
AU - Tambaro, Rosa
AU - Papini, Stefano
AU - Farina, Giuliana
AU - Piano, Silvia
AU - Zappacosta, Bruno
AU - Storti, Sergio
PY - 2009
Y1 - 2009
N2 - In neoplastic patients chemotherapy frequently involves severe myeloid suppression. Sometimes myeloid suppression is the main cause of therapy recycling delay with severe and prolonged neutropenia, anaemia and thrombocytopenia. Our study aimed to verify whether there is a correlation between reticulocyte fractions, reticulocyte indices, myeloperoxidase index (MPXI) and post-chemotherapy myelopoietic function and severe post-chemotherapy neutropenia. A cohort of 112 patients was identified, 30 with lymphoma or myeloma and 82 with solid neoplasms with bone marrow micrometastases. The patients were treated with chemotherapy (CT). After CT, 60 patients had neutropenia (ANC 10.7% a score of 1, and a score of 0 was assigned to the remaining patients. Patients with a score of 1 showed a lower number of neutropenic events (only 9 out of 36 patients) than those with a score of 0 (51 out of 76 patients), p
AB - In neoplastic patients chemotherapy frequently involves severe myeloid suppression. Sometimes myeloid suppression is the main cause of therapy recycling delay with severe and prolonged neutropenia, anaemia and thrombocytopenia. Our study aimed to verify whether there is a correlation between reticulocyte fractions, reticulocyte indices, myeloperoxidase index (MPXI) and post-chemotherapy myelopoietic function and severe post-chemotherapy neutropenia. A cohort of 112 patients was identified, 30 with lymphoma or myeloma and 82 with solid neoplasms with bone marrow micrometastases. The patients were treated with chemotherapy (CT). After CT, 60 patients had neutropenia (ANC 10.7% a score of 1, and a score of 0 was assigned to the remaining patients. Patients with a score of 1 showed a lower number of neutropenic events (only 9 out of 36 patients) than those with a score of 0 (51 out of 76 patients), p
KW - Chemotherapy
KW - Medium absorbance fraction of reticulocyte
KW - Myeloperoxidase index
KW - Neutropenia
UR - http://www.scopus.com/inward/record.url?scp=61449285741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61449285741&partnerID=8YFLogxK
U2 - 10.3892/or_00000207
DO - 10.3892/or_00000207
M3 - Article
C2 - 19082461
AN - SCOPUS:61449285741
VL - 21
SP - 193
EP - 198
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 1
ER -